2011 Fiscal Year Final Research Report
Cadherin-mediated reconstitution mechanism of human endometrial epithelial cells during implantation研究代表者:
| Project/Area Number |
21592108
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Tetsuo 慶應義塾大学, 医学部, 講師 (10209702)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 生殖医学 / 着床 |
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| Research Abstract |
Human endometrial epithelial cell(EEC) layer, which is structural and immunological barrier, is temporally disrupted by penetration of fertilized egg in the process of pregnancy, however the reconstruction mechanism of disrupted EEC layer is largely unknown. This study demonstrated that epithelial mesenchymal transition is involved in the mechanism in association with redistribution of N-cadherin. These results are useful for the new strategy of assisted reproductive technology.
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Research Products
(16 results)
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[Journal Article] Psychological adjustment and psychosocial stress among Japanese couples with a history of recurrent pregnancy loss2012
Author(s)
Kagami M, Maruyama T, Koizumi T, Miyazaki K, Nishikawa-Uchida S, Oda H, Uchida H, Fujisawa D, Ozawa N, Schmidt L, Yoshimura Y
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Journal Title
Hum Reprod
Volume: 27
Pages: 787-794
Peer Reviewed
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[Journal Article] Stem cell-like properties of the endometrial side population : implication in endometrial regeneration2010
Author(s)
Masuda H, Matsuzaki Y, Hiratsu E, Ono M, Nagashima T, Kajitani T, Arase T, Oda H, Uchida H, Asada H, Ito M, Yoshimura Y, Maruyama T, Okano H
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Journal Title
PLoS One
Volume: 5
Pages: e10387
Peer Reviewed
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[Journal Article] The UDP-glucose receptor P2RY14 triggers innate mucosal immunity in the female reproductive tract by inducing IL-82009
Author(s)
Arase T, Uchida H, Kajitani T, Ono M, Tamaki K, Oda H, Nishikawa S, Kagami M, Nagashima T, Masuda H, Asada H, Yoshimura Y, Maruyama T
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Journal Title
J Immunol
Volume: 182
Pages: 7074-7084
Peer Reviewed
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[Presentation] N-Cadherin and RhoA Have Opposite Effects on the Regulation of Endometrial Epithelial Cell Migration during Implantation2010
Author(s)
Uchida H, Maruyama T, Arase, T, Ono M, Kajitani, T, Kagami, M, Oda, H, Nishikawa, S, Yoshimura Y
Organizer
57th Society for Gynecologic Investigation
Place of Presentation
Orland, Florida, USA
Year and Date
20100324-27
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