2011 Fiscal Year Final Research Report
Analysis of the lipoxygenase and its signaling pathway involved in the pathophysiology of endometriosis
| Project/Area Number |
21592110
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Tetuso 慶應義塾大学, 医学部, 講師 (10209702)
UCHIDA Hiroshi 慶應義塾大学, 医学部, 助教 (90286534)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 子宮内膜症 / 疼痛 / リポキシゲナーゼ / ロイコトリエン / リポキシン / 脂質メディエーター |
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| Research Abstract |
The purpose of this research project was to elucidate the role of the lypoxygenase(LOX) and its signaling pathway in the pathogenesis and pathophysiology of endometriosis. We demonstrated that 5-LOX and 15-LOX mRNA were up-regulated in endometrioma compared to normal eutopic endometrium, whereas 12-LOX mRNA levels did not differ between them. These results collectively suggest that the LOX pathway may be, at least in part, involved in the pathophysiology of endometriosis. We have also developed several types of in vivo mouse model of endometrisois using severely immunodeficient mice as a research tool to explore the role of LOX and its signaling pathway in endometriosis.
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[Journal Article] Stem Cell-Like Properties of the Endometrial Side Population : Implication in Endometrial Regeneration2010
Author(s)
Masuda H, Matsuzaki Y, Hiratsu E, Ono M, Nagashima T, Kajitani T, Arase T, Oda H, Uchida H, Asada H, Ito M, Yoshimura Y, Maruyama T, Okano H
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Journal Title
PLoS ONE
Volume: 5(4)
Pages: e10387
Peer Reviewed
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[Journal Article] 腹水と血清中における代謝物質の網羅的分析による子宮内膜症特異的な代謝物質の探索2010
Author(s)
川田陽子, 島田友恵, 浅田弘法, 杉本昌弘, 平山明由, 阿部しのぶ, 古谷正敬, 内田浩, 浜谷敏生, 梶谷宇, 丸山哲夫, 久慈直昭, 吉村泰典, 曽我朋義, 富田勝
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Journal Title
日本エンドメトリオーシス学会会誌
Volume: 31
Pages: 210-212
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[Journal Article] The UDP-glucose recepter P2RY14 triggers innate mucosal immunity in the female reproductive tract by inducing IL-82009
Author(s)
Arase T, Uchida H, Kajitani T, Ono M, TamakiK, Oda H, Nishikawa S, Kagami M, Nagashima T, Masuda H, Asada H, Yoshimura Y, Maruyama T
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Journal Title
J Immunol
Volume: 182(11)
Pages: 7074-7084
Peer Reviewed
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[Presentation] Possible involvement of endometrial stem/progenitor cells in the pathogenesis of endocetriosis2010
Author(s)
Tetsuo Maruyama, Hirotaka Masuda, Takashi Nagashima, Takashi Kajitani, Masanori Ono, Sayaka Nishikawa-Uchida Hideyuki Oda, Kaoru Miyazaki, Toru Arase, Maki Kagami, Hiroshi Uchida Hironori Asada, Yasunori Yoshimura
Organizer
1st Asian Conference on Endometriosis(ACE)
Place of Presentation
Shanghai, China
Year and Date
20101016-17
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