2011 Fiscal Year Final Research Report
Therapeutic potentials of parasitic antigens on a murine recurrent spontaneous abortion
| Project/Area Number |
21592114
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
相澤 志保子 日本大学, 医学部, 助手 (30513858)
泉 泰之 日本大学, 医学部, 研究員 (50459872)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 習慣流産 / 免疫機序 / 寄生虫抗原 / Th17 |
|---|
| Research Abstract |
The mammalian fetuses are semi-allograft for mothers. Therefore the failure of immunological tolerance often causes pregnancy loss. We revealed therapeutic potential of the recombinant antigen from a nematoda parasite, Dirofilaria immitis rDiAg with a murine recurrent spontaneous abortion model.(CBA/J×DBA/2J) The rDiAg treatment significantly reduced the resorption rates of mouse model, which mimic human pregnancy failures with allo-immune backgrounds.
Serum IL-4, IL-23 and TNF-α concentrations were significantly lower in rDiAg-treated mice than mock-treated mice. The serum IL-17 level was also reduced in rDiAg-treated mice but the difference was not significant. Our observations suggest as the first time of therapeutic potentials of parasites for pregnancy loss.
|
-
-
-
-
-
-
[Journal Article] Influence of advanced age on Mycobacterium bovis BCG vaccination in guinea pigs aerogenically infected with Mycobacterium tuberculosis2010
Author(s)
Komine-Aizawa S, Yamazaki T, Yamazaki T, Hattori S, Miyamoto Y, Yamamoto N, Haga S, Sugitani M, Honda M, Hayakawa S, Yamamoto S
-
Journal Title
Clin Vaccine Immunol
Volume: 17(10)
Pages: 1500-6
-
-
-
-
-
-
