2011 Fiscal Year Final Research Report
Profiling and functional analyses of microRNAs in ovarian theca cells
| Project/Area Number |
21592115
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIBASHI Osamu 日本医科大学, 医学部, 講師 (70293214)
TAKESHITA Toshiyuki 日本医科大学, 大学院・医学研究科, 教授 (60188175)
TAKIZAWA Toshihiro 日本医科大学, 大学院・医学研究科, 教授 (90271220)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 婦人科学 / 卵巣 / 卵胞 / 莢膜細胞 / 多嚢胞性卵巣症候群 / microRNA |
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| Research Abstract |
We performed miRNA profiling of isolated mouse thecal stem cells from neonatal mouse ovary and in vitro differentiating theca cells. We investigated differential miRNA signatures between thecal stem cells and differentiating cells by real-time PCR-based miRNA array analysis. During theca cell differentiation, 30 miRNAs were upregulated, and 9 miRNAs were downregulated. Ingenuity pathway analysis indicates that these miRNAs participate in reproductive system disease, genetic disorder, cellular development, cellular growth and proliferation, and cell cycles.
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Research Products
(14 results)
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[Presentation] 胎盤由来のエクソソーム:胎盤特異的microRNAはエクソソームを介して母体循環に分泌される2011
Author(s)
瀧澤俊広, アリハメド, 羅善順, 石橋宰, 菊池邦生, 石川朋子, 瀧澤敬美, 倉品隆平, 右田真, 大口昭英, 松原茂樹, 竹下俊行
Organizer
第84回日本生化学会大会
Place of Presentation
京都
Year and Date
2011-09-22
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[Presentation] 胎盤特異的microRNAは絨毛栄養膜由来でありエクソゾームを介して母体血液中に放出される2010
Author(s)
瀧澤俊広, 石橋宰, 羅善順, 石川源, 石川朋子, 三嶋拓也, 瀧澤敬美, 後藤忠, 泉章夫, 大口昭英, 松原茂樹, 竹下俊行
Organizer
第115回日本解剖学会総会・全国学術集会
Place of Presentation
岩手
Year and Date
2010-03-28
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