2011 Fiscal Year Final Research Report
The role of micro-RNA in carcinogenesis and development of uterine papillary serous carcinoma(UPSC)
| Project/Area Number |
21592120
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tohoku University |
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Principal Investigator |
NAGASE Satoru 東北大学, 大学院・医学系研究科, 准教授 (00292326)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 子宮体癌 / 子宮体部漿液性腺癌 / 類内膜腺癌 / マイクロRNA / 発現プロファイル |
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| Research Abstract |
We compared miRNA expression levels in uterine papillary serous carcinoma (UPSC)with the levels in endometrial endometrioid adenocarcinoma (EEC)and normal endometria. Eight miRNAs were identified as having aberrant down-regulation specific to UPSC with miR-34b being most pronounced. Ectopic expression of miR-34b inhibited cell growth, migration, and most notably invasion. These effects are likely mediated by the downstream target of miR-34b, the proto-oncogene MET, a known prognostic factor in endometrial carcinomas. The expression of MET was reduced following the restoration of miR-34b in cell lines. In summary, our data suggest that miR-34b plays a role in the molecular pathogenesis of ESC.
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