2011 Fiscal Year Final Research Report
To investigate of anti-neoplastic effect of metformin in endometrial cancer
| Project/Area Number |
21592123
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHOZU Makio 千葉大学, 大学院・医学研究院, 教授 (30226302)
USUI Hirokazu 千葉大学, 大学院・医学研究院, 講師 (90375634)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 子宮内膜癌 / メトホルミン |
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| Research Abstract |
1) The anti-neoplastic activity of metformin was observed in vitro and in vivo in endometrial cancer cell lines and in patients with endometrial cancer. Metformin appears to be a useful therapy in the prevention and treatment of patients with endometrial cancer.
2) The recurrence rate in our study was lower than that observed in the previous study. Metformin may inhibit endometrial cancer recurrence after MPA therapy. Metformin also improved insulin resistance in young endometrial cancer patients who were at risk of developing diabetes mellitus.
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