2011 Fiscal Year Final Research Report
Novel strategy to control the differentiation of macrophages in ascites for the suppression of ovarian cancer dissemination
| Project/Area Number |
21592137
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATABUCHI Hidetaka 熊本大学, 大学院・生命科学研究部, 教授 (90224451)
TAKAISHI Kiyomi 熊本大学, 医学部附属病院, 助教 (00601303)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 婦人科腫瘍学 / 卵巣癌 / 腹膜播種 / 腹腔マクロファージ / STAT3 / colosoric acid |
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| Research Abstract |
Ascites macrophages in advanced epithelial ovarian cancer(AdEOC) are involved in cancer metastasis and progression by modifying the tumor microenvironment. We investigated the function of macrophages in the ascites of advanced epithelial ovarian cancers and the cell-to-cell interactions between macrophages and EOC cells through Stat3 activation. M2 macrohpages in the ascitic fluid may influence epithelial ovarian cancer development via STAT3 activation. Macrohages differentiation could be targeted for development of anticancer therapeutic drugs. Furthermore, corosolic acid(CA), a triterpenoid compound, is contained in the leaves of the banaba plant(Lagerstroemia speciosa L.). The compound possesses various biological properties, including anti-diabetic, anti-obesity and anti-oxidative activities. We investigated the cytotoxicity of CA against human ovarian cancer cell lines. CA inhibited the proliferation of ovarian cancer cells by suppressing the activation of STAT3. Therefore, CA might be a potential new tool for tumor prevention and therapy.
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