2011 Fiscal Year Final Research Report
Development of mice model for inquiry into therapeutic targets : an anticancer effect of dienogest on endometrial neoplasm
| Project/Area Number |
21592138
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
SAKAGUCHI Isao 熊本大学, 医学部附属病院, 助教 (40448527)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KATABUCHI Hidetaka 熊本大学, 大学院・生命科学研究部, 教授 (90224451)
TASHIRO Hironori 熊本大学, 医学部附属病院, 特任准教授 (70304996)
SAITO Fumitaka 熊本大学, 医学部附属病院, 診療助手 (20555742)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 子宮内膜癌 / PTEN遺伝子 / 黄体ホルモン / 遺伝子改変マウス / Cre-loxPシステム |
|---|
| Research Abstract |
Hormonal therapy for type I(endometrioid) endometrial cancer is employed as a conservative treatment among young nulligravida women. However the success rate of therapy with hormonal agents is not very high, and these agents often have serious adverse effects. Thus, new agents with a higher efficacy and fewer side effects would be highly desirable. Dienogest is a synthetic progestational steroid that is used for the treatment of endometriosis, but its anticancer activity remains unknown. We investigated the anticancer effect of dienogest on endometrial neoplasm by using mice based on conditional PTEN deletion within the endometrium, a genetic model of endometrial cancer. Medroxyprogesterone acetate(MPA) and dienogest were administered subcutaneously for 1weeks to evaluate the antitumor effect against complex atypical hyperplasia(CAH) and endometrial cancer which developed in mice. Without progestins treatment, 5 of 6 mice developed endometrial neoplasms(atypical hyperplasia or adenocarcinoma). On the other hands, 7 of 8 mice treated with MPA and 5 of 6 mice treated with gienogest showed a no signs of CAH or endometrial cancer. Dienogest showed potent anticancer activity, as well as MPA, against endometrial neoplasms in mice. We conclude that dienogest may be a useful therapeutic agent for endometrial neoplasms.
|
Research Products
(11 results)
-
-
-
[Journal Article] Evidenced-based guideline for treatment of uterine body neoplasm in Japan : Japan Society of Gynecologic Oncology2010
Author(s)
Nagase S, Katabuchi H, Hiura M, Sakuragi N, Aoki Y, Kigawa J, Saito T, Hachisuga T, Ito K, Uno T, Katsumata S, Susumu N, Emoto M, Kobayashi H, Metoki H, Konishi I, Ochiai K, Mikami M, Sugiyama T, Mukai M, Sagae S, Hoshiai H, Aoki D, Ohmiri M, Yoshikawa H
-
Journal Title
International Journal of Clinical Oncology
Volume: 15
Pages: 531-542
Peer Reviewed
-
[Journal Article] Asian society of gynecologic oncology workshop 20102010
Author(s)
Suh DH, Kim JW, Aziz MF, Devi UK, Ngan HY, Nam JH, Kim SC, Kato T, Ryu HS, Fujii S, Lee YS, Kim JH, Kim YT, Wang KL, Lee TS, Ushijima K, Shin SG, Chia YN, Wilailak S, Park SY, Katabuchi H, Kamura T, Kang SB
-
Journal Title
Journal of Gynecologic Oncology
Volume: 21
Pages: 137-150
Peer Reviewed
-
-
-
-
-
-
-
