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2011 Fiscal Year Final Research Report

The role of adiponectin and resistin in the pathogenesis of postmenopausal metabolic syndrome

Research Project

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Project/Area Number 21592142
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionFukushima Medical University

Principal Investigator

SATOH Hiroaki  福島県立医科大学, 医学部, 准教授 (20323595)

Co-Investigator(Kenkyū-buntansha) MIDORIKAWA Sanae  福島県立医科大学, 医学部, 講師 (10325962)
WATANABE Tsuyoshi  福島県立医科大学, 医学部, 講師 (80158641)
Project Period (FY) 2009 – 2011
Keywords更年期医学 / インスリン抵抗性 / アディポサイトカイン
Research Abstract

To investigate the physiological role of Adipo and Res in the postmenopausal, estrogen-deficient state, we studied the chronic in vivo effect of Adipo and Res on insulin sensitivity in young ovariectomized female Wistar rats. Estrogen-deficient state had significantly increased body weight and decreased insulin sensitivity. Adiponectin improves the estrogen deficiency induced insulin resistance, whereas resistin exacerbates the estrogen deficiency induced insulin resistance. Furthermore, we found that AMPK is a key molecule player in muscle and liver.
These results that the insulin resistance has been involved in the incidence of diabetes increases as women age, especially after menopause.

  • Research Products

    (17 results)

All 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (11 results)

  • [Journal Article] Pioglitazone upregulates adiponectin receptor 2 in 3T3-L1 adipocytes2011

    • Author(s)
      Kudoh A, Satoh H, Hirai H, Watanabe T
    • Journal Title

      Life Sci

      Volume: 88 Pages: 1055-1062

    • Peer Reviewed
  • [Journal Article] Adiponectin reduces proteinuria in streptozotocin-induced diabetic Wistar rats.2011

    • Author(s)
      Nakamaki S, Satoh H, Kudoh A, Hayashi Y, Hirai H, Watanabe T
    • Journal Title

      Exp Biol Med(Maywood)

      Volume: 236 Pages: 614-620

    • Peer Reviewed
  • [Journal Article] MEN1型に合併した内分泌腫瘍からの異所性GHRH産生による先端巨大症とその治療経験(原著論文/症例報告)2011

    • Author(s)
      緑川早苗, 片上秀喜, 渡辺聡子, 待井典剛, 平井裕之, 工藤明宏, 長谷川浩司, 佐藤博亮, 渡辺毅
    • Journal Title

      日本内分泌学会雑誌

      Volume: 87 Pages: 69-71

    • Peer Reviewed
  • [Journal Article] 2型糖尿病合併高血圧患者に対する他のARBからアバプロR(イルべサルタン)への切り替え効果~アバプロRのドラックエフェクトを示唆する知見2011

    • Author(s)
      緑川早苗、佐藤博亮、渡辺毅
    • Journal Title

      血圧Journal of Blood Pressure

      Volume: 17 Pages: 954-960

    • Peer Reviewed
  • [Journal Article] 内頸動脈瘤により視床下部性汎下垂体機能低下症をきたした1例(原著論文/症例報告)2009

    • Author(s)
      本間美優樹, 緑川早苗, 菅谷芳幸, 平井裕之, 工藤明宏, 長谷川浩司, 藤原淳, 中嶋真一, 佐藤博亮, 渡辺毅
    • Journal Title

      日本内分泌学会雑誌

      Volume: 85 Pages: 33-35

    • Peer Reviewed
  • [Journal Article] 糖尿病を合併する高血圧に対するバルサルタン高用量の降圧効果2009

    • Author(s)
      佐藤博亮、平井裕之、工藤明宏、長谷川浩司、藤原淳、緑川早苗、渡辺毅
    • Journal Title

      血圧Journal of Blood Pressure

      Volume: 16(9) Pages: 797-800

    • Peer Reviewed
  • [Presentation] The High Potassium Intake Improves High Fat Diet Induced Insulin Resistance in Male Wistar Rats.2011

    • Author(s)
      Satoh H, Sugaya Y, Kudoh A, Yamazaki S, Machii N, Watanabe S, Hirai H, Hasegawa K, Nakajima S, Midorikawa S, Watanabe T.
    • Organizer
      71^<st> American Diabetes Association Scientific Sessions
    • Place of Presentation
      San Diego CA
    • Year and Date
      20110624-28
  • [Presentation] 「DM合併症の管理を考える」糖尿病性慢性合併症の発症進展とインスリン抵抗性2010

    • Author(s)
      佐藤博亮, 渡辺毅
    • Organizer
      第37回東北腎不全研究会
    • Place of Presentation
      新潟市
    • Year and Date
      20100828-29
  • [Presentation] Impairment of insulin sensitivity via reactive oxygen species in muscle cells2010

    • Author(s)
      Kudoh A, Satoh H, Hirai H, Yamazaki S, Sugaya Y, Machii N, Hasegawa K, Watanabe S, Nakajima S, Midorikawa S, Watanabe T.
    • Organizer
      第42回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      岐阜県岐阜市
    • Year and Date
      20100715-16
  • [Presentation] The Mechanisms by Which Two Kinds of PPAR gamma Agonists Improve Insulin Sensitivity and Increases Body Weight in Type 2 Diabetic Patients.2010

    • Author(s)
      Satoh H, Kudoh A, Hirai H, Hasegawa K, Fujiwara M, Watanabe T.
    • Organizer
      70^<th> American Diabetes Association Scientific Sessions
    • Place of Presentation
      Orlando, FL
    • Year and Date
      20100625-29
  • [Presentation] Amenorrhea resulting from polycystic ovary syndrome(PCOS) secondary to growth hormone(GH) producing pituitary adenoma2010

    • Author(s)
      Watanabe S, Midorikawa S, Sugaya Y, Honma M, Machii N, Hirai H, Kudoh A, Hasegawa K, Fujiwara F, Nakajima N, Satoh H, Watanabe T.
    • Organizer
      14^<th> International Congress of Endocrinology(ICE2010)
    • Place of Presentation
      Kyoto
    • Year and Date
      20100326-30
  • [Presentation] Comparison two kinds of PPAR_γ agonist, pioglitazone or telmisartan, on circulating total adiponectin and its multimer distribution in patients with type 2 diabetes2010

    • Author(s)
      Satoh H, Kudoh K, Hirai H, Yamazaki S, Hasegawa K, Fujiwara F, Watanabe S, Sugaya Y, Machii N, Honma M, Nakajima S, Midorikawa S, Watanabe T
    • Organizer
      14^<th> International Congress of Endocrinology(ICE2010)
    • Place of Presentation
      Kyoto, JAPAN
    • Year and Date
      20100326-30
  • [Presentation] アディポネクチンのSTZ糖尿病ラットにおける蛋白病減少効果とその機序の検討2009

    • Author(s)
      佐藤博亮、平井裕之、工藤明宏、中牧慎太郎、長谷川浩司、藤原淳、本間美優樹、中嶋真一、緑川早苗、渡辺毅
    • Organizer
      第13回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      さいたま市
    • Year and Date
      20091023-24
  • [Presentation] The Mechanisms by which Pioglitazone Improves Insulin Sensitivity and Increases Body Weight in Patients with Type 2 Diabetes Mellitus2009

    • Author(s)
      Hirai H, Satoh H, Kudoh A, Hasegawa K, Yamazaki S, Sugaya Y, Fujiwara M, Honma M, Nakajima S, Midorikawa S, Watanabe T
    • Organizer
      69^<th> American Diabetes Association Scientific Sessions
    • Place of Presentation
      New Orleans, LA
    • Year and Date
      20090605-09
  • [Presentation] Adenovirus-mediated chronic expression of adiponectin improves early stage diabetic nephropathy in STZ induced diabetic Wistar rats2009

    • Author(s)
      Satoh H, Nakamaki S, Kudoh A, Hirai H, Yamazaki S, Sugaya Y, Hasegawa K, Fujiwara M, Honma M, Nakajima S, Midorikawa S, Watanabe T
    • Organizer
      69^<th> American Diabetes Association Scientific Sessions
    • Place of Presentation
      New Orleans, LA
    • Year and Date
      20090605-09
  • [Presentation] エンドセリン-1の3T3-L1脂肪細胞からレジスチン分泌に及ぼす影響とその作用機序2009

    • Author(s)
      工藤明宏、佐藤博亮、平井裕之、菅谷芳幸、長谷川浩司、藤原淳、本間美優樹、中嶋真一、緑川早苗、渡辺毅
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20090521-24
  • [Presentation] 2型糖尿病患者におけるヤーコンの糖・脂質代謝に及ぼす影響についての検討2009

    • Author(s)
      佐藤博亮、工藤明宏、長谷川浩司、平井裕之、藤原淳、菅谷芳幸、本間美優樹、中嶋真一、緑川早苗、渡辺毅
    • Organizer
      第82回内分泌学会学術総会
    • Place of Presentation
      群馬県前橋市
    • Year and Date
      20090423-24

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Published: 2013-07-31  

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