2011 Fiscal Year Final Research Report
Analysis of carbohydrate structures related to metastasis of gynecologic cancers and establishment of human monoclonal antibodies towards these carbohydrate structures
| Project/Area Number |
21592145
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOMINAGA Eiichiro 慶應義塾大学, 医学部, 助教 (80276328)
SUZUKI Masami 慶應義塾大学, 医学部, 共同研究員 (10276321)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 婦人科癌 / 抗体医療 / 糖鎖抗原 / モノクローナル抗体 |
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| Research Abstract |
We have developed a gynecologic cancer-specific human monoclonal antibody HMOCC-1 that demonstrates anti-tumor activity towards ovarian cancer, among gynecologic cancers. The antibody has a specific carbohydrate antigen epitope that is a sulfated carbohydrate moiety. The carbohydrate antigen recognized by this antibody is a newly characterized epitope present on gynecologic cancers and its glycan structure was elucidated to be SO3→3Galβ1→4GlcNAcβ1→3(±SO3→6) Galβ1→4GlcNAcβ1→.
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[Journal Article] Identification of mono-and di-sulfated N-acetyl-lactosaminyl oligosaccharide structures as epitopes specifically recognized by humanized monoclonal antibody HMOCC-1 raised against ovarian cancer2012
Author(s)
Shibata T, Matsumura F, Wang P, Yu SY, Khoo KH, Kitayama K, Akama T, Sugihara K, Kojima-Aikawa K, Seeberger P, Fukuda M, Suzuki A, Aoki D, Fukuda MN
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Journal Title
J. Biol Chem
Volume: 287(9)
Pages: 6592-6602
Peer Reviewed
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[Journal Article] Identification of ANXA4, PSAT1, CRABP2 and SPB5 as histology-specific biomarker candidates for ovarian cancer by proteomic characterization2012
Author(s)
Toyama A, Suzuki A, Shimada T, Aoki C, Aoki Y, Umino Y, Nakamura Y, Aoki D, Sato T
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Journal Title
Cancer Sci
Volume: 103(4)
Pages: 747-55
Peer Reviewed
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[Journal Article] The sensitivity and specificity of a new formula to distinguish endometrioid type endometrial carcinoma from ovarian endometrial carcinoma2010
Author(s)
Nishimura S, Ito YM, Tsuda H, Ohnishi Y, Kataoka F, Nomura H, Chiyoda T, Suzuki A, Susumu N, Aoki D, Hatae M
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Journal Title
Eur J Obstet Gynecol Reprod Biol
Volume: 148(1)
Pages: 67-72
Peer Reviewed
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[Journal Article] Amplification of GNAS may be an independent, qualitative and reproducible biomarker to predict progression-free survivial in epithelial ovarian cancer2010
Author(s)
Tominaga E, Tsuda H, Arao T, Nishimura S, Takano M, Kataoka F, Nomura H, Hirasawa A, Aoki D, Nishio K
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Journal Title
Gynecol. Oncol
Volume: 118(2)
Pages: 160-6
Peer Reviewed
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