• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2011 Fiscal Year Final Research Report

Immunological prevention of age-related hearing loss : analysis of its molecular biological mechanisms

Research Project

  • PDF
Project/Area Number 21592170
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionKansai Medical University

Principal Investigator

IWAI Hiroshi  関西医科大学, 医学部, 准教授 (10232638)

Co-Investigator(Kenkyū-buntansha) INABA Muneo  関西医科大学, 医学部, 非常勤講師 (70115947)
Project Period (FY) 2009 – 2011
Keywords老人性難聴 / 免疫老化 / IL-1R2 / CD4^+T細胞 / 胎児胸腺 / Treg / 浸透圧ポンプ
Research Abstract

We found that rejuvenation of the recipient immunity by inoculation of young CD4^+T cells or a fetal thymus graft led to down regulation of the interleukin 1 receptor type II(IL-1R2) gene in CD4^+T cells and reduced age-related hearing loss in SAMP1 mice, a murine model of human senescence. Our studies on the relationship between age-related systemic immune dysfunctions and neurodegeneration mechanisms open up new avenues of treatment of neurosenescence, including presbycusis, for which there is no effective therapy.

  • Research Products

    (10 results)

All 2011 2010 2009 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (5 results)

  • [Journal Article] Amelioration of 2, 4, 6-trinitrobenzene sulfonic acid-induced colitis in mice by immunoregulatory dendritic cells2011

    • Author(s)
      Hoshino S, Kurishima A, Inaba M, Ando Y, Fukui T, Uchida K, Nishio A, Iwai H, Yokoi T, Ito T, Hasegawa-Ishii S, Shimada A, Li M, Okazaki K, Ikehara S
    • Journal Title

      J Gastroenterol

      Volume: 46 Pages: 1368-81

    • Peer Reviewed
  • [Journal Article] The role of dendritic cell subsets in 2, 4, 6-Trinitrobenzene sulfonic acid-induced ileitis2010

    • Author(s)
      Hoshino S, Inaba M, Iwai H, Ito T, Li M, Gershwin ME, Okazaki K, Ikehara S
    • Journal Title

      J Autoimmunity

      Volume: 34 Pages: 380-389

    • Peer Reviewed
  • [Journal Article] Induction of parotitis by fine-needle aspiration in parotid Warthin's tumor2009

    • Author(s)
      Suzuki S, Iwai H, Kaneko T, Sakaguchi M, Hoshino S, Inaba M
    • Journal Title

      Otolaryngol Head Neck Surg

      Volume: 141 Pages: 282-284

    • Peer Reviewed
  • [Journal Article] Parotid mucosa-associated lymphoid tissue lymphoma regression after Helicobacter Pylori eradication2009

    • Author(s)
      Iwai H, Nakamichi N, Nakae K, Konishi M, Inaba M, Hoshino S, Baba S. Amakawa R
    • Journal Title

      Laryngoscopel

      Volume: 19 Pages: 1491-1494

    • Peer Reviewed
  • [Journal Article] Fetal Thymus Graft Prevents Age-Related Hearing Loss and Up Regulation of the IL-1 Receptor Type II Gene in CD4^+T cells

    • Author(s)
      Iwai H, Inaba M
    • Journal Title

      J Neuroimmunol

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] Fetal Thymus Graft Prevents Presbycusis and Age-Related Up Regulation of The IL-1 Receptor Type II Gene in Helper T cells2011

    • Author(s)
      Iwai H, Inaba M, Baba S, Tomoda K
    • Organizer
      The 48th Inner Ear Biology Workshop
    • Place of Presentation
      Lisbon, Portugal
    • Year and Date
      20110918-24
  • [Presentation] Immunological and genetical influence of systemic helper T cell on age-related cochlear functions2010

    • Author(s)
      Iwai H, Inaba M, Baba S, Sakaguchi M, Ikehara S, Tomoda T
    • Organizer
      47th Inner Ear Biology Workshop
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      20100829-0901
  • [Presentation] T細胞機能維持による進行性老人性難聴予防2009

    • Author(s)
      岩井大、坂口麻理子、馬場奨、李進隆、友田幸一
    • Organizer
      第19回日本耳科学会
    • Year and Date
      20091008-10
  • [Presentation] Inoculation of helper T cells as a strategy for the prevention of age-related hearing loss in SAMP1 mice2009

    • Author(s)
      Iwai H, Baba, Inaba M, Sakaguchi M, Lee S, Ikehara S, Tomoda K
    • Organizer
      48th Workshop on Inner Ear Biology
    • Place of Presentation
      Utreht, The Netherland
    • Year and Date
      20090912-15
  • [Presentation] Preventive effects of thymus graft on age-related hearing loss2009

    • Author(s)
      Baba S, Iwai H, Inaba M, Sakaguchi M, Lee S, Ikehara S, Tomoda K
    • Organizer
      48th Workshop on Inner Ear Biology
    • Place of Presentation
      Utreht, The Netherland
    • Year and Date
      20090912-15

URL: 

Published: 2013-07-31  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi