2011 Fiscal Year Final Research Report
Role of epithelial cells in the pathomechanisms of allergic rhinitis-interaction with T cells and dendritic cells
| Project/Area Number |
21592181
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Nippon Medical School |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 鼻アレルギー / 上皮細胞 / 樹状細胞 / T細胞 |
|---|
| Research Abstract |
TSLP expression was detected in epithelial cells and mast cells of the nasal mucosa from allergic and non allergic rhinitics and nasal polyps from atopics and non-atopics. The expression of TSLP was highest in nasal polyps from atopics as compared to allergic nasal mucosa and non-atopic nasal polyps. The expression of Th2 chemokines like TARC and MDC were also increased. Both in allergic nasal mucosa and atopic nasal polyps there was a good correlation between the TSLP+cells and IgE and TSLP+cells and eosinophils. House dust mite stimulation of nasal epithelial cells resulted in increased TSLP secretion. There was a good correlation between TSLP and CCR4+cells and CCR4+cells with IL-4 and IL-13.
|
Research Products
(11 results)
