2011 Fiscal Year Final Research Report
Investigation of microRNA expression by nasal and paranasal fibroblasts
| Project/Area Number |
21592182
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Tokyo Women's Medical University (2010-2011)
Nippon Medical School (2009) |
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Principal Investigator |
NONAKA Manabu 東京女子医科大学, 医学部, 准教授 (70271351)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 鼻副鼻腔 / microRNA / 線維芽細胞 / 呼吸器 |
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| Research Abstract |
Primary fibroblast lines were established from human nasal and lung tissues. We looked at the expression of microRNA induced by cutokines. miR-146a was induced by TGF-βin lung fibroblast lines, but not in nasal fibroblast lines. IL-4/IL-13 and TNF-α induced the production of TSLP as well as miR-375 in nasal fibroblasts.
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