2011 Fiscal Year Final Research Report
Study on thickened cell wall in clinical macrolide-resistant Staphylococcus aureus isolates.
| Project/Area Number |
21592183
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
YAMADA Sakuo 川崎医科大学, 医学部, 准教授 (00122458)
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| Co-Investigator(Kenkyū-buntansha) |
HARADA Tamotsu 川崎医科大学, 医学部, 教授 (30165021)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 黄色ブドウ球菌 / 細胞壁 / 肥厚 / マクロライド / ゲンタマイシン / 耐性菌 |
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| Research Abstract |
The clinical macrolide(ML)-resistant Staphylococcus aureus strains showed a thickened cell wall when compared morphologically with the clinical ML-sensitive S. aureus strains. We also demonstrated that gentamycin-resistant clinical isolates of S. aureus exhibited a thickened cell wall. These results strongly suggest that a thickened cell wall is a common ultrastractural characteristic of protein synthesis inhibitor antibiotics-resistant S. aureus clinical strains.
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