2011 Fiscal Year Final Research Report

Invastigations on High Molecular Weight-Melanoma Associated Antigen as a target of the immunotherapy

Research Project

Project/Area Number	21592185
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Otorhinolaryngology
Research Institution	Asahikawa Medical College
Principal Investigator	KATAYAMA Akihiro 旭川医科大学, 医学部, 助教 (40374805)
Co-Investigator(Kenkyū-buntansha)	YOSHINO Kazumi 旭川医科大学, 耳鼻科・医学部, 医員 (60516722) TOTANI Toshitaka 旭川医科大学, 耳鼻科・医学部, 医員 (40516720)
Project Period (FY)	2009 – 2011
Keywords	頭頚部外科学
Research Abstract	We have investigated the expression of High Molecular Weight-Melanoma Associated Antigen in human head and neck squamous cell carcinoma cells, and found CSPG4 expression not only on the cell surface of HNSCC cells but also clinical samples. Moreover, we have established the scFv specific for High Molecular Weight-Melanoma Associated Antigen utilizing genetic engineering techniques. In Vivo study utilizing SCID mice xenograft model inoculated with various human malignant cell lines, our scFv specific for High Molecular Weight-Melanoma Associated Antigen clearly inhibited proliferation and metastasis of the tumor cells.