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2012 Fiscal Year Final Research Report

Research of the mechanism of lymph node metastasis in nasopharyngeal carcinoma with bio-assay model

Research Project

  • PDF
Project/Area Number 21592189
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionKanazawa University

Principal Investigator

WAKISAKA Naohiro  金沢大学, 大学病院, 講師 (70377414)

Co-Investigator(Renkei-kenkyūsha) YOSHIZAKI Tomokazu  金沢大学, 医学系, 教授 (70262582)
MURONO Shigeyuki  金沢大学, 大学病院, 講師 (20345622)
KONDO Satoru  金沢大学, 附属病院, 助教 (70436822)
Project Period (FY) 2009 – 2012
KeywordsEBV / LMP1 / VEGF-C / リンパ管新生 / リンパ節転移 / 上咽頭癌 / 動物モデル / 胸管
Research Abstract

The involvement of vascular endothelial growth factor (VEGF)-C/VEGF receptor-3 axis in the induction of lymphangiogenesis results in lymphatic spread of nasopharyngeal carcinoma. However, Epstein-Barr virus-associated latent membrane protein-1 was not associated with the mechanism.Knowing the status of lymphangiogenesis in the regional lymph nodes in tongue cancer would help in predicting which patients will develop nodal recurrence. Thus, therapeutic approach which blocks lymphangiogenic factors may be beneficial in suppressing the lymphatic spread of tongue cancer with intense intranodal lymphangiogenesis.

  • Research Products

    (16 results)

All 2012 2011 2009

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Book (1 results)

  • [Journal Article] Warthin's tumor associated with IgG4-related disease.2012

    • Author(s)
      Aga M, Kondo S, Yamada K, Sawada-Kitamura S, Yagi-Nakanishi S, Endo K,Wakisaka N, Murono S, Kawano M, Yoshizaki T
    • Journal Title

      Auris NasusLarynx

    • DOI

      DOI:10.1016/j.anl.2012.11.005

    • Peer Reviewed
  • [Journal Article] Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: Novel prognostic factors of nasopharyngeal carcinoma2012

    • Author(s)
      Kitagawa N, Kondo S, Wakisaka N, Zen Y, Nakanishi Y, Tsuji A, Endo K, Murono S, Yoshizaki T
    • Journal Title

      Cancer Lett. Epub

    • DOI

      DOI:10.1016/j.canlet.2012.12.002

    • Peer Reviewed
  • [Journal Article] Tumor-targeted chemotherapy with the nanopolymer-based drug NC-6004 for oral squamous cell carcinoma.2012

    • Author(s)
      Endo K, Ueno T, Kondo S, Wakisaka N, Murono S, Ito M, Kataoka K, Kato Y,Yoshizaki T
    • Journal Title

      Cancer Sci. Epub

    • DOI

      DOI:10.1111/cas.12079

    • Peer Reviewed
  • [Journal Article] Oncological and functional outcome after transoral 532-nm pulsed potassium-titanyl-phosphate laser surgery for T1a glottic carcinoma2012

    • Author(s)
      Murono S, Endo K, Kondo S, Wakisaka N, Yoshizaki T
    • Journal Title

      Lasers Med Sci. Epub

    • DOI

      DOI:10.1007/s10103-012-1121-4

    • Peer Reviewed
  • [Journal Article] Lymphangiogenesis in regional lymph nodes predicts nodal recurrence in pathological N0 squamous cell carcinoma of the tongue.2012

    • Author(s)
      Hirota K, Wakisaka N, Sawada-Kitamura S, Kondo S, Endo K, Tsuji A, Murono S,Yoshizaki T
    • Journal Title

      Histopathology

      Volume: 61(6) Pages: 1065-71

    • DOI

      DOI:10.1111/j.1365-2559.2012.04341.x

    • Peer Reviewed
  • [Journal Article] Adjuvant chemotherapy withan oral fluoropyrimidine, S-1, following reduced RADPLAT in advanced laryngeal cancer2012

    • Author(s)
      Wakisaka N, Kondo S, Endo K, Murono S, Yoshizaki T
    • Journal Title

      Ann Otol Rhinol Laryngol

      Volume: 121(8) Pages: 555-62

    • Peer Reviewed
  • [Journal Article] Induction of lymphangiogenesis through vascular endothelial growth factor-C/vascular endothelial growth factor receptor 3 axis and its correlation with lymph node metastasis in nasopharyngeal carcinoma2012

    • Author(s)
      Wakisaka N, Hirota K, Kondo S, Sawada-Kitamura S, Endo K, Murono S, Yoshizaki T
    • Journal Title

      Oral Oncol

      Volume: 48(8) Pages: 703-8

    • DOI

      DOI: 10.1016/j.oraloncology.2012.02.003

    • Peer Reviewed
  • [Journal Article] Efficacy and safety of garenoxacin in the treatment of upperrespiratory tract infections.2012

    • Author(s)
      Ito M, Maruyama Y, Murono S, Wakisaka N, Kondo S, Hatano M, Nakanishi S, MiwaT, Yoshizaki T
    • Journal Title

      Auris Nasus Larynx

      Volume: 39(5) Pages: 512-8

    • DOI

      DOI:10.1016/j.anl.2011.09.004

    • Peer Reviewed
  • [Journal Article] Current understanding and management of nasopharyngeal carcinoma2012

    • Author(s)
      Yoshizaki T, Ito M, Murono S, Wakisaka N, Kondo S, Endo K
    • Journal Title

      Auris Nasus Larynx

      Volume: 39(2) Pages: 137-44

    • DOI

      DOI:10.1016/j.anl.2011.02.012

    • Peer Reviewed
  • [Journal Article] Epstein-Barr virus latent membrane protein 1 inducescancer stem/progenitor-like cells in nasopharyngeal epithelial cell lines2011

    • Author(s)
      Kondo S, Wakisaka N, Muramatsu M, Zen Y, Endo K, Murono S, Sugimoto H, YamaokaS, Pagano JS, Yoshizaki T
    • Journal Title

      Jvirol

      Volume: 85(21) Pages: 11255-64

    • DOI

      DOI: 10.1128/JVI.00188-11

    • Peer Reviewed
  • [Journal Article] Epidemiological analysis ofnasopharyngeal carcinoma in the central region of Japan during the period from 1996 to 2005.2011

    • Author(s)
      Kimura Y, Suzuki D, Tokunaga T, Takabayashi T, Yamada T, Wakisaka N, Yoshizaki T, Murata H, Miwa K, Shoujaku H, Watanabe Y, Yamada N, Ito Y, Yuta A, Takeuchi K,Hosokawa S, Mineta H, Hasegawa Y, Fujimoto Y, Nakashima T, Fujieda S
    • Journal Title

      Auris Nasus Larynx

      Volume: 38(2) Pages: 244-9

    • DOI

      DOI:10.1016/j.anl.2010.07.006

    • Peer Reviewed
  • [Journal Article] Pseudoaneurysm of the lingual artery after concurrent intra-arterial chemotherapy with radiotherapy for advanced tongue cancer.2011

    • Author(s)
      Murono S, Nakanishi Y, Inoue D, Ozaki K, Kondo S, Wakisaka N, Matsui O,Yoshizaki T
    • Journal Title

      Head Neck

      Volume: 33(8) Pages: 1230-2

    • DOI

      DOI:10.1002/hed.21372

    • Peer Reviewed
  • [Journal Article] Discerning regulation of cis- and trans-presentation of CD8+ T-cell epitopes by EBV-encoded oncogene LMP-1 through self-aggregation.2009

    • Author(s)
      Smith C, Wakisaka N, Crough T, Peet J, Yoshizaki T, Beagley L, Khanna R
    • Journal Title

      Blood

      Volume: 113(24) Pages: 6148-52

    • DOI

      DOI:10.1182/blood-2009-02-203687

    • Peer Reviewed
  • [Journal Article] An extremely rare case of large Delphian node metastasis preceding primary laryngeal cancer.2009

    • Author(s)
      Murono S, Hirota K, Kondo S, Wakisaka N, Furukawa M, Yoshizaki T
    • Journal Title

      Auris Nasus Larynx

      Volume: 36(5) Pages: 614-7

    • DOI

      DOI:10.1016/j.anl.2009.01.010

    • Peer Reviewed
  • [Journal Article] A solitary fibrous tumor arising in the parapharyngeal space, with MRI and FDG-PET findings.2009

    • Author(s)
      Wakisaka N, Kondo S, Murono S, Minato H, Furukawa M, Yoshizaki T
    • Journal Title

      Auris Nasus Larynx

      Volume: 36(3) Pages: 367-71

    • DOI

      DOI:10.1016/j.anl.2008.05.010

    • Peer Reviewed
  • [Book] 上咽頭癌2012

    • Author(s)
      脇坂尚宏, 吉崎智一
    • Total Pages
      200-205
    • Publisher
      中山書店

URL: 

Published: 2014-08-29  

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