Immunomonitoring in head and neck cancer patients treated with protein vaccine through tumor destruction

2011 Fiscal Year Final Research Report

• Project/Area Number: 21592191
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Mie University
• Principal Investigator: KAGEYAMA Shinichi 三重大学, 大学院・医学系研究科, 准教授 (80194695)
• Co-Investigator(Kenkyū-buntansha): YUTA Atsushi 三重大学, 大学院・医学系研究科, リサーチアソシエイト (80293778)
• Project Period (FY): 2009 – 2011
• Keywords: がんワクチン / 臨床試験 / 免疫モニタリング

Research Abstract

Immune reactions in head/neck cancer patients treated with protein vaccine, recombinant MAGE-A4 protein complexed with cholesteryl pullulan, were analyzed. 16 subjects including head/neck cancer patients completed 6 or more vaccination. Humoral IgG responses were analyzed with ELISA assay. 3 patients were positive for MAGE-A4 antibody prior vaccination, suggesting that there exists natural positive immunity in MAGE-A4 antigen positive cancer patients. Among them, MAGE-A4 immunity was augmented in one case. In 4 MAGE-A4 antibody negative patients, 2 converted to MAGE-A4 IgG positive. Spreading of immune reactions other than vaccinated antigen was observed.

Research Products

• [Journal Article] 治療用がんワクチン開発のためのFDAからのガイダンス (2011)
  • Author(s): 影山愼一
  • Journal Title: 腫瘍内科 Volume: 8巻 Pages: 167-171
• [Journal Article] CHPがん蛋白ワクチン (2011)
  • Author(s): 影山愼一
  • Journal Title: 腫瘍内科 Volume: 8巻 Pages: 446-451
• [Journal Article] Randomized trial of response-oriented individualized versus fixed-schedule induction chemotherapy with idarubicin and cytarabine in adult acute myeloid leukemia (2010)
  • Author(s): Ohtake S, Miyawaki S, Kiyoi H, Miyazaki Y, Okumura H, Matsuda S, Nagai T, Kishimoto Y, Okada M, Takahashi M, Handa H, Takeuchi J, Kageyama S, Asou N, Yagasaki F, Maeda Y, Ohnishi K, Naoe T
  • Journal Title: JALSG AML95 study Int J Hematol Volume: 91 Pages: 276-283
  • Peer Reviewed
• [Journal Article] Antibody responses against NY-ESO-1 and HER2 antigens in patientsvaccinated with combinations of cholesteryl pullulan(CHP)-NY-ESO-1 and CHP-HER2 with OK-432 (2009)
  • Author(s): Aoki M, Ueda S, Nishikawa H, Kitano S, Hirayama M, Ikeda H, Toyoda H, Tanaka K, Kanai M, Takabayashi A, Imai H, Shiraishi T, Sato E, Wada H, Nakayama E, Takei Y, Katayama N, Shiku H, Kageyama S
  • Journal Title: Vaccine Volume: 27 Pages: 6854-6861
  • Peer Reviewed
• [Presentation] 疎水化多糖・タンパクがんワクチンTRからのレッスン (2011)
  • Author(s): 影山愼一
  • Organizer: 第49回日本癌治療学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-10-28
• [Presentation] CHP-抗原蛋白のがんワクチン橋渡し研究 (2011)
  • Author(s): 影山愼一
  • Organizer: 第14回日本がん免疫学会総会
  • Place of Presentation: 熊本市
  • Year and Date: 2011-07-22
• [Presentation] MAGE-A4抗原を発現する難治性悪性腫瘍に対するCHP-MAGE-A4がんワクチン臨床試験(第I+ II相試験) (2010)
  • Author(s): 影山愼一, 他
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-24
• [Presentation] MAGE-A4抗原を発現する非小細胞性肺癌細胞株におけるMAGE-A4発現の検討 (2010)
  • Author(s): 影山愼一, 他
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-24
• [Presentation] CHP-抗原がんワクチンのトランスレーショナルリサーチを通じた得られた成果と課題 (2010)
  • Author(s): 影山愼一
  • Organizer: 第13回日本がん免疫学会総会
  • Place of Presentation: 北九州市
  • Year and Date: 2010-06-24
• [Presentation] OK-432を用いたCHP-NY-ESO-1蛋白ワクチンにより誘導されたCD4+ T細胞の解析 (2009)
  • Author(s): 影山愼一, 他
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-10-01
• [Book] がん免疫療法-実用化へのチャレンジ (2010)
  • Author(s): 影山愼一
  • Total Pages: 250
  • Publisher: シーエムシー出版
• [Remarks]
  • URL: http://www.shikuken.jp/