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2011 Fiscal Year Final Research Report

Identification of tissue specific stem cell of the vocal fold

Research Project

  • PDF
Project/Area Number 21592192
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionKyoto University

Principal Investigator

HIRANO Shigeru  京都大学, 医学研究科, 講師 (10303827)

Co-Investigator(Kenkyū-buntansha) 金丸 眞一  田附興風会北野病院, 耳鼻咽喉科, 部長 (00271510)
楯谷 一郎  京都大学, 医学研究科, 助教 (20526363)
Project Period (FY) 2009 – 2011
Keywords喉頭 / 声帯 / 再生 / 幹細胞 / 創傷治癒 / FACS / SP細胞 / 表面マーカー
Research Abstract

The current research aimed to indentify tissue specific stem cell of the vocal fold using SP cells. However, although SP cell could be separated, collection and culture of the cells turned out to be technically difficult. Then it was attempted to pick up SP cells during wound healing of the vocal folds using rat models and ABCG antibody. The results showed increased expression of SP cells during early wound healing period. Characterization of the cells using surface markers is under way. The third project aimed to examine regenerative effects of stem cells for the vocal fold. Bone marrow derived mesenchymal stem cells were used for regeneration of scarred vocal folds in a canine model. The results were encouraging with positive effects on histology and function of the regenerated vocal folds.

  • Research Products

    (16 results)

All 2012 2011 2010 Other

All Journal Article (5 results) Presentation (10 results) Remarks (1 results)

  • [Journal Article] Laryngealregeneration using tissue engineering techniques in a canine model2011

    • Author(s)
      Kitani Y, Kanemaru S, Umeda H, Suehiro A, Kishimoto Y, Hirano S, Nakamura T, Ito J
    • Journal Title

      Ann Otol Rhinol Laryngol

      Volume: 120 Pages: 49-56

  • [Journal Article] Implantation of an atelocollagen sponge with autologous bone marrow derived mesenchymal stromal cells for treatment of vocal fold scarring in a canine model Ann Otol Rhinol2011

    • Author(s)
      Ohno S, Hirano S, Kanemaru S, Kitani Y, Kojima T, Tateya I, Nakamura T, Ito J.
    • Journal Title

      Laryngol

      Volume: 120 Pages: 401-408

  • [Journal Article] Recruitmentpatterns of side population cells during wound healing in rat vocal folds2011

    • Author(s)
      Gugatschka M, Kojima T, Ohno S, Kanemaru S, Hirano S.
    • Journal Title

      Laryngoscope

      Volume: 121 Pages: 1662-1667

  • [Journal Article] Temporal changesin vocal functions of human scarredvocal folds after cordectomy2010

    • Author(s)
      Kishimoto Y, Hirano S, Tateya I, Kanemaru S, Ito J.
    • Journal Title

      Laryngoscope

      Volume: 120 Pages: 1597-601

  • [Journal Article] Implantation of atelocollagen sheet for vocal fold scar2010

    • Author(s)
      Kishimoto Y, Welham NV, Hirano S
    • Journal Title

      Curr Opin Otolaryngol Head Neck Surg

      Volume: 18(6) Pages: 507-511

  • [Presentation] Advances for the treatment of scar of the vocal folds2012

    • Author(s)
      Hirano S.
    • Organizer
      17th Int' l workshop on laser voice surgery
    • Place of Presentation
      Paris
    • Year and Date
      20120330-31
  • [Presentation] Vocal fold wound healing and regeneration2011

    • Author(s)
      Hirano S.
    • Organizer
      11th Japan Taiwan Conference on Otolaryngology
    • Place of Presentation
      Kobe
    • Year and Date
      20111208-09
  • [Presentation] Implantation of an atelocollagen sponge with bone marrow derived stromal cells for the treatment of vocal fold scarring2011

    • Author(s)
      Ohno S, Hirano S, Kanemaru S, Kitani Y, Kojima T, Tateya I, Nakamura T, Ito J
    • Organizer
      91th American Bronchoesophagological Association Meeting
    • Place of Presentation
      Chicago
    • Year and Date
      20110428-29
  • [Presentation] Laryngeal reconstruction with tissue engineering technique using acellular extracellular matrix scaffold2011

    • Author(s)
      Kitamura M, Hirano S, Kitani Y, Ohno S, Kojima T, Kanemaru S, Ito J, Rosen C, Gilbert T
    • Organizer
      91th American Bronchoesophagological Association Meeting
    • Place of Presentation
      Chicago
    • Year and Date
      20110428-29
  • [Presentation] Current management of vocal fold scar. New surgical treatment option2010

    • Author(s)
      Hirano S.
    • Organizer
      4th World Voice Congress
    • Place of Presentation
      Seoul
    • Year and Date
      20100906-09
  • [Presentation] Expression of side population cells during wound healing of rat vocal folds2010

    • Author(s)
      Kojima T, Hirano S, Tateya I, Kanemaru S, Nakamura T, Ito J
    • Organizer
      ICVPB
    • Place of Presentation
      Madison
    • Year and Date
      20100606-09
  • [Presentation] Two staged laryngeal regeneration using tissue engineering tachniques in a canine model2010

    • Author(s)
      Kitani Y, Kanemaru S, Hirano S, Ohno S, Kojima T, Ito J.
    • Organizer
      113th Triological Society
    • Place of Presentation
      Las Vegas
    • Year and Date
      20100430-0501
  • [Presentation] Cutting edge of healing process ofvocal cord in 20102010

    • Author(s)
      Hirano S.
    • Organizer
      15th Int' l workshop on laser voice surgery
    • Place of Presentation
      Paris
    • Year and Date
      20100409-10
  • [Presentation] Regeneration of vocal fold mucosa with tissue engineering strategy2010

    • Author(s)
      Hirano S.
    • Organizer
      7th East Asian Conference on Phonosurgery
    • Place of Presentation
      Tokyo
    • Year and Date
      2010-11-29
  • [Presentation] Regeneration of vocal fold : translational research from bench to bed2010

    • Author(s)
      Hirano S.
    • Place of Presentation
      Grand roung at Cornell University
    • Year and Date
      2010-07-01
  • [Remarks] ホームページ

    • URL

      http://www.kuhp.kyoto-u.ac.jp/~ent/new/index.

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Published: 2013-07-31   Modified: 2014-11-19  

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