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2011 Fiscal Year Final Research Report

Stat3 targeted therapy in head and neck cancer

Research Project

  • PDF
Project/Area Number 21592195
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionKyushu University

Principal Investigator

MASUDA Muneyuki  九州大学, 医学研究院, 共同研究員 (90284504)

Co-Investigator(Renkei-kenkyūsha) SUZU Masum  名古屋市立大学, 教授 (30347158)
FUJII Masato  東京医療センター, 臨床研究センター (70129633)
Project Period (FY) 2009 – 2011
KeywordsStat3 / 分子標的 / CIN85
Research Abstract

In head and neck squamous cell carcinoma(HNSCC), the frequent overexpression of EGFR is associated with the constitutive activation of Stat3. We analyzed the effects of Cbl interacting protein of 85 kDa(CIN85), which is involved in ligandinduced internalization of EGFR, focusing on EGFR signaling pathways. It was expected that CIN85 might exert inhibitory effects on EGFR signaling, thus leading to tumor inhibition. However, on the contrary, CIN85 was overexpressed in 40% of HNSCC tumor samples and this overexpression was significantly associated with advanced clinical stage. Mechanistic studies, in vitro, demonstrated that upon TGF-alpha stimuli, CIN85 activated MAPK cascade but inhibited Stat3 activity. Thus, it is suggested that in HNSCC, EGFR promotes carcinogenesis utilizing at least two different signaling axis : EGFR-CIN85-MAPK or EGFRStat3.

  • Research Products

    (9 results)

All 2011 2010 2009

All Journal Article (5 results) Presentation (4 results)

  • [Journal Article] Chemoprevention of Head and Neck Cancer by Green Tea Extract : EGCG-The Role of EGFR Signaling and" Lipid Raft2011

    • Author(s)
      Masuda M, Wakasaki T, Ton S, Shimizu M, Adachi S
    • Journal Title

      J Oncol

      Volume: 2011 Pages: 540148

  • [Journal Article] Moriwaki H. Cancer chemoprevention with green tea catechins by targeting receptor tyrosine kinases2011

    • Author(s)
      himizu M, Adachi S, Masuda M, Kozawa 0
    • Journal Title

      Mol Nutr Food Res

      Volume: 55(6) Pages: 832-43

  • [Journal Article] A critical role of cCblinteracting protein of 85 kDa in the development and progression of head and neck squamous cell carcinomas through the ras-ERK pathway2010

    • Author(s)
      Wakasaki T, Masuda M, Niiro H, JabbarzadehTabrizi S, Neda K, Taniyama T, Komune S, Akashi K
    • Journal Title

      Neoplasia

      Volume: 12(10) Pages: 789-96

  • [Journal Article] Stats3 orchestrates tumor development and progression : the Achilles' heel. of head and neck cancers2010

    • Author(s)
      Masuda M, Wakasaki T, Suzui M, Ton S, Joe AK, Weinstein IB
    • Journal Title

      Curr Cancer Drug Target

      Volume: 10 Pages: 117-126

  • [Journal Article] a multiadoptpr protein, predominantlytransmitss the EGFR signnal to the MAPK cascadeanceen hencee tumor proliferation in HNSCC2009

    • Author(s)
      Wakasaki T, Masuda M, Niiro H, Komune S, Akashi K. CIN8s5
    • Journal Title

      Oral Oncol

      Volume: 3(1) Pages: 211

  • [Presentation] 上咽頭腺癌に対するcombi ned-cervi cal and trans orbit ozygomatic approach2011

    • Author(s)
      益田宗幸,福島淳一,藤村晶子,江島正義,瓜生英興
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      20110609-10
  • [Presentation] A critical role of a c-abl interacting protein of 85 kd in the development and progression of head and neck squamous cell carcinoa via the ras-ERK pathway2010

    • Author(s)
      Wakasaki T, Masuda M, Niiro H, Komune S
    • Organizer
      AHNS 2010 researech workshop on the biology
    • Place of Presentation
      Arlington, VA
    • Year and Date
      20101028-30
  • [Presentation] Cbl i ht exact i Ig prot el n of 85 KDa(OIN85) predomnantly transmits EGFR si gnat to MAPKcascade, and enhance tumor progressi on i n head and neck squarxnus cell carci noma2009

    • Author(s)
      若崎高裕,益田宗幸,新納宏昭,赤司浩一,小宗静男
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      20091001-03
  • [Presentation] CIN8s5, a mult-iadoptpr protein, predominantlytransmitss the EGFR signnal to the MAPK cascadeanceen hencee tumor proliferation in HNSCC2009

    • Author(s)
      Wakasaki T, Masuda M, Niiro H, Komune S, Akashi K.
    • Organizer
      2nd World Congress of the International Academy of Oral Oncology
    • Place of Presentation
      Toronto
    • Year and Date
      20090708-11

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Published: 2013-07-31  

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