2011 Fiscal Year Final Research Report
Morphological studies on the chemoreceptors of spontaneously hypertensive rats(SHR).
| Project/Area Number |
21592202
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUSAKABE Tatsumi 国士舘大学, 体育学部, 教授 (80117663)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 高血圧 / 低酸素 / 化学受容器 / 特殊臓性知覚 / 組織化学 |
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| Research Abstract |
The carotid bodies, which are located at the carotid bifurcation and are the primary chemoreceptive organs for sensing changes in arterial blood gases, became significantly enlarged in spontaneously hypertensive rats(SHR). In spite of enlargement, there was no obvious vascular enlargement in SHR. SHR showed a significant increase in extracellular matrix in the carotid body. These results indicate that the mechanism of carotid body enlargement in SHR is different from that in hypoxic animals. In addition, the present studies suggest facilitated noradrenaline biosynthesis in chemoreceptor cells of carotid bodies in SHR.
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Author(s)
M. Mori, M. Tsukuda, H. Matsuda, C. Hori uchi, T. Taguchi, M. Takahashi, G. Ni shimura, M. Komatsu, T. Niho, N. Sakuma, A. Miyakoshi, Y. Isono, S. Iwahana
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Journal Title
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[Journal Article] Effi-cacy of fluoro-2-deoxy-D-glucose po-sitron emission tomography to evalu-ate responses to concurrent chemo-radiotherapy for head and neck squamous cell carcinoma2011
Author(s)
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Journal Title
Auris Nasus Larynx
Volume: 38
Pages: 724-729
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[Journal Article] Randomized cont-rolled phase II comparison study of concurrent chemoradiotherapy with docetaxel, cisplatin, and 5-fluoro-uracil versus CCRT with cisplatin, 5-fluorouracil, Cancer Chemother2010
Author(s)
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Journal Title
Phar-macol
Volume: 66
Pages: 729-736
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[Journal Article] Efficacy of concurrent chemoradiotherapy for T1 and T2 laryngeal squamous cell carcinoma regarding organ pre-servation2009
Author(s)
G. Nishimura, M. Tsukuda, M. Mikami, H. Matsuda, C. Horiuchi, T. Taguchi, M. Takahashi, M. Kawakami, M. Watanabe, T. Niho, H. Abo, S. Yamomoto
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Journal Title
Anticancer Res
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