2011 Fiscal Year Final Research Report
Development of devices for retinal protection
| Project/Area Number |
21592214
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tohoku University |
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Principal Investigator |
ABE Toshiaki 東北大学, 大学院・医学系研究科, 教授 (90191858)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAI Nobuhiro 東北大学, 大学院・医学系研究科, 助教 (30400039)
KAJI Kazuhiro 東北大学, 大学院・工学研究科, 助教 (70431525)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 網膜保護 / デバイス / ドラックデリバリーシステム / 新生血管 / コラーゲン / PEG |
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| Research Abstract |
We aimed the creation of a new device that secretes a drug for retinal protection and suppresion of choraidal neovascularization (CNV). We also aimed the sustained delivery of the drug, safety of the device and easily to be taken out the devices.
The devices were made from a sustained-release film and the reservoir using triethylene glycol dimethacrylate (TEGDM), polyethylene glycol dimethacrylate (PEGDM), and collagen particles with UV irradiation. When we used vasohibin-1 for the loaded drug in the devices, the released vasohibin-1 was found to inhibit the proliferation of endothelial cells (HUVEC)in vitro. We put the device on rat sclera and examined for a rat model of CNV using intense photocoagulation, and the effect was considered significantly when compared to that of non-vasohibin releasing device by fluorescein photography and measurement of the CNV area. Fabrication of the device can make the results exactly the sustained release of drug. We may be abe to use the device from transscleral drug delivery one for retinal diseases.
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[Journal Article] Suppression of Choroidal Neovascularization by Vasohibin-1, Vascular Endothelium-derived Angiogenic Inhibitor2011
Author(s)
Wakusawa R, Abe T, Sato H, Sonoda H, Sato M, Mitsuda Y, Takakura T, Fukushima T, Onami H, Nagai N, Ishikawa Y, Nishida K, and Sato Y
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 17 ; 52(6)
Pages: 3272-3280
Peer Reviewed
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[Journal Article] Suppression of phagocytic cells in retinal disorders using amphiphilic poly(γ-glutamic acid)nanoparticles containing dexamethasone2011
Author(s)
Ryu M, Nakazawa T, Akagi T, Tanaka T, Watanabe R, Yasuda M, Himori N, Maruyama K, Yamashita T, Abe T, Akashi M, Nishida K
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Journal Title
J Control Release
Volume: 151(1)
Pages: 65-73
Peer Reviewed
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