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2011 Fiscal Year Final Research Report

Development of devices for retinal protection

Research Project

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Project/Area Number 21592214
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionTohoku University

Principal Investigator

ABE Toshiaki  東北大学, 大学院・医学系研究科, 教授 (90191858)

Co-Investigator(Kenkyū-buntansha) NAGAI Nobuhiro  東北大学, 大学院・医学系研究科, 助教 (30400039)
KAJI Kazuhiro  東北大学, 大学院・工学研究科, 助教 (70431525)
Project Period (FY) 2009 – 2011
Keywords網膜保護 / デバイス / ドラックデリバリーシステム / 新生血管 / コラーゲン / PEG
Research Abstract

We aimed the creation of a new device that secretes a drug for retinal protection and suppresion of choraidal neovascularization (CNV). We also aimed the sustained delivery of the drug, safety of the device and easily to be taken out the devices.
The devices were made from a sustained-release film and the reservoir using triethylene glycol dimethacrylate (TEGDM), polyethylene glycol dimethacrylate (PEGDM), and collagen particles with UV irradiation. When we used vasohibin-1 for the loaded drug in the devices, the released vasohibin-1 was found to inhibit the proliferation of endothelial cells (HUVEC)in vitro. We put the device on rat sclera and examined for a rat model of CNV using intense photocoagulation, and the effect was considered significantly when compared to that of non-vasohibin releasing device by fluorescein photography and measurement of the CNV area. Fabrication of the device can make the results exactly the sustained release of drug. We may be abe to use the device from transscleral drug delivery one for retinal diseases.

  • Research Products

    (52 results)

All 2012 2011 2010 2009 Other

All Journal Article (32 results) (of which Peer Reviewed: 32 results) Presentation (16 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Journal Article] Vasohibin-1 and retinal pigment epithelium2012

    • Author(s)
      Ishikawa Y, Nagai N, Onami H, Kumasaka N, Wakusawa R, Sonoda H, Sato Y, Abe T
    • Journal Title

      Adv Med Exp Biol

    • Peer Reviewed
  • [Journal Article] Reduction of laser-induced choroidal neovascularization by intravitreal vasohibin-1 in monkey eyes2012

    • Author(s)
      Onami H, Nagai N, Machida S, Kumasaka N, Wakusawa R, Ishikawa Y, Sonoda H, Sato Y, Abe T
    • Journal Title

      RETINA

    • Peer Reviewed
  • [Journal Article] A scalable controlled release device for transscleral drug delivery to the retina2011

    • Author(s)
      Kawashima T, Nagai N, Kaji H, Kumasaka N, Onami H, Ishikawa Y, Osumi N, Nishizawa M, and Abe T
    • Journal Title

      Biomaterials

      Volume: 32(7) Pages: 1950-1956

    • Peer Reviewed
  • [Journal Article] Fixating Dislocated Intraocular Lens by 25-Gauge Vitrectomy2011

    • Author(s)
      Kunikata H, Fuse N, Abe T
    • Journal Title

      Ophthalmic Surgery, Lasers & Imaging

      Volume: 42(4) Pages: 297-301

    • Peer Reviewed
  • [Journal Article] Nishida K Successful outcomes of 25-and 23-gauge vitrectomies for giant retinal tear detachments2011

    • Author(s)
      Kunikata H, Abe T, Nishida K
    • Journal Title

      Ophthalmic Surgery, Lasers & Imaging

      Volume: 8 Pages: 1-6

    • Peer Reviewed
  • [Journal Article] Nishida K Difficulty in Inserting 25-and 23-gauge Trocar-cannula during Vitrectomy2011

    • Author(s)
      Kunikata H Nitta F, Meguro Y, Aizawa N, Hariya T, Chiba N, Abe T, Nishida K
    • Journal Title

      Ophthalmologica

      Pages: 198-204

    • Peer Reviewed
  • [Journal Article] Enzymatic biofuel cells designed for direct power generation from biofluids in living organisms2011

    • Author(s)
      Miyake T, Haneda K, Nagai N, Yatagawa Y, Ohnami H, Yoshino S, Abe T, and Nishizawa M
    • Journal Title

      Energy & Environmental Science

      Pages: 5008-5012

    • Peer Reviewed
  • [Journal Article] Suppression of Choroidal Neovascularization by Vasohibin-1, Vascular Endothelium-derived Angiogenic Inhibitor2011

    • Author(s)
      Wakusawa R, Abe T, Sato H, Sonoda H, Sato M, Mitsuda Y, Takakura T, Fukushima T, Onami H, Nagai N, Ishikawa Y, Nishida K, and Sato Y
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 17 ; 52(6) Pages: 3272-3280

    • Peer Reviewed
  • [Journal Article] Suppression of phagocytic cells in retinal disorders using amphiphilic poly(γ-glutamic acid)nanoparticles containing dexamethasone2011

    • Author(s)
      Ryu M, Nakazawa T, Akagi T, Tanaka T, Watanabe R, Yasuda M, Himori N, Maruyama K, Yamashita T, Abe T, Akashi M, Nishida K
    • Journal Title

      J Control Release

      Volume: 151(1) Pages: 65-73

    • Peer Reviewed
  • [Journal Article] Polymorphisms in ARMS2 (LOC387715)and LOXL1 Genes in Japanese with Age-related Macular Degeneration2011

    • Author(s)
      Fuse N, MingGe Mengkegale, Miyazawa A, Abe T, Nakazawa T, Wakusawa R and Nishida K
    • Journal Title

      Am J Ophthalmol

      Volume: 151 Pages: 550-556

    • Peer Reviewed
  • [Journal Article] Heat shock protein 70 (HSP70)is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase2011

    • Author(s)
      Kayama M, Nakazawa T, Thanos A, Morizane Y, Murakami Y, Theodoropoulou S, Abe T, Vavvas D and Miller JW
    • Journal Title

      Am J Pathol

      Volume: 178(3) Pages: 1080-1091

    • Peer Reviewed
  • [Journal Article] Preoperative factors predictive of postoperative decimal visual acuity > 1. 0 following surgical treatment for idiopathic epiretinal membrane2011

    • Author(s)
      Kunikata H, Abe T, Kinukawa J, Nishida K
    • Journal Title

      Clinical Ophthalmology

      Volume: 5 Pages: 147-154

    • Peer Reviewed
  • [Journal Article] A microfluidic-based neurotoxin concentration gradient for the generation of an in vitro model of Parkinson's disease2011

    • Author(s)
      Seidi A, Kaji H, Annabi N, Ostrovidov S, Ramalingam M, Khademhosseini A
    • Journal Title

      Biomicrofluidics

      Volume: 5 Pages: 022214

    • Peer Reviewed
  • [Journal Article] Directed assembly of cell-laden microgels for building porous three-dimensional tissue constructs2011

    • Author(s)
      Yanagawa F, Kaji H, Jang YH, Bae H, Yanan D, Fukuda J, Qi H, Khademhosseini A
    • Journal Title

      J. Biomed. Mater. Res. A 97A

      Pages: 93-102

    • Peer Reviewed
  • [Journal Article] Engineering systems for the generation of patterned co-cultures for controlling cell-cell interactions2011

    • Author(s)
      Kaji H, Camci-Unal G, Langer R, Khademhosseini A
    • Journal Title

      Biochim. Biophys. Acta-Gen. Subj

      Volume: 1810 Pages: 239-250

    • Peer Reviewed
  • [Journal Article] Evaluation of retinal degeneration in P27KlP1 null mice2010

    • Author(s)
      Tokita-Ishikawa Y, Wakusawa R, Abe T
    • Journal Title

      Adv Exp Med Biol

      Volume: 664 Pages: 467-471

    • Peer Reviewed
  • [Journal Article] Preparation and characterization of collagen microspheres for sustained release of VEGF2010

    • Author(s)
      Nagai N, Kumasaka N, Kawashima T, Kaji H, Nishizawa M, Abe T
    • Journal Title

      J Mater Sci Mater Med

      Volume: 21(6) Pages: 1891-1898

    • Peer Reviewed
  • [Journal Article] Patterned differentiation of individual embryoid bodies in spatially organized 3D hybrid microgels2010

    • Author(s)
      Qi H, Du Y, Wang L, Kaji H, Bae H, Khademhosseini A
    • Journal Title

      Adv. Mater

      Volume: 22 Pages: 5276-5281

    • Peer Reviewed
  • [Journal Article] Monitoring impedance changes associated with motility and mitosis of a single cell2010

    • Author(s)
      Ghenim L, Kaji H, Hoshino Y, Ishibashi T, Haguet V, Gidrol X, Nishizawa M
    • Journal Title

      Lab Chip

      Volume: 10 Pages: 2374-2379

    • Peer Reviewed
  • [Journal Article] Electrically induced contraction of C2C12 myotubes cultured on a porous membrane-based substrate with muscle tissue-like stiffness2010

    • Author(s)
      Kaji H, Ishibashi T, Nagamine K, Kanzaki M, Nishizawa M
    • Journal Title

      Biomaterials

      Volume: 31 Pages: 6981-6986

    • Peer Reviewed
  • [Journal Article] Directing the flow of medium in controlled cocultures of HeLa cells and human umbilical vein endothelial cells with a microfluidic device2010

    • Author(s)
      Kaji H, Yokoi T, Kawashima T, Nishizawa M
    • Journal Title

      Lab Chip

      Volume: 10 Pages: 2374-2379

    • Peer Reviewed
  • [Journal Article] Electrodes combined with an agarose stamp for addressable micropatterning2010

    • Author(s)
      Sekine S, Nakanishi S, Miyake T, Nagamine K, Kaji H, Nishizawa M
    • Journal Title

      Langmuir

      Volume: 26 Pages: 11526-11529

    • Peer Reviewed
  • [Journal Article] Micropatterning Contractile C2C12 Myotubes Embedded in a Fibrin Gel2010

    • Author(s)
      Nagamine K, Kawashima T, Ishibashi T, Kaji H, Kanzaki M, Nishizawa M
    • Journal Title

      Biotechnol. Bioeng

      Volume: 105 Pages: 1161-1167

    • Peer Reviewed
  • [Journal Article] Transfer of two-dimensional patterns of human umbilical vein Eendothelial cells into fibrin gels to facilitate vessel formation2010

    • Author(s)
      Kawashima T, Yokoi T, Kaji H, Nishizawa M
    • Journal Title

      Chem. Commun

      Volume: 46 Pages: 2070-2072

    • Peer Reviewed
  • [Journal Article] Vitreous Levels of Vasohibin-1 and Vascular Endothelial Growth Factor in Patients with Proliferative Diabetic Retinopathy2009

    • Author(s)
      Sato H, Abe T, Wakusawa R, Asai N, Kunikata H, Ohta Sonoda H, Sato Y, Nishida K
    • Journal Title

      Diabetologia

      Volume: 52 Pages: 359-361

    • Peer Reviewed
  • [Journal Article] TrkB-T1 Receptors on Muller Cells Play Critical Role in Brain-Derived Neurotrophic Factor-Mediated Photoreceptor Protection against Phototoxicity2009

    • Author(s)
      Saito T, Abe T, Wakusawa R, Sato H, Asai N, Tokita-Ishikaws Y, and Nishida K
    • Journal Title

      CURRENT EYE RESEARCH

      Volume: 34(7) Pages: 580-588

    • Peer Reviewed
  • [Journal Article] Panretinal photocoagulation induces pro-inflammatory cytokines and macular thickening in high-risk proliferative diabetic retinopathy2009

    • Author(s)
      Shimura M, Yasuda K, Nakazawa T, Abe T
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 247 Pages: 1617-1624

    • Peer Reviewed
  • [Journal Article] Axisymmetric polydimethysiloxane microchannels for in vitro hemodynamic studies2009

    • Author(s)
      Lima R, Oliveira M, Ishikawa T, Kaji H, Tanaka S, Nishizawa M, Yamaguchi M
    • Journal Title

      Biofabrication

      Volume: 1 Pages: 035005

    • Peer Reviewed
  • [Journal Article] Spatiotemporal subcellular biopatterning using an AFM-assisted electrochemical system2009

    • Author(s)
      Kaji H
    • Journal Title

      Electrochem. Commun

      Volume: 11 Pages: 1781-1784

    • Peer Reviewed
  • [Journal Article] Selective capture of a specific cell type from mixed leucocytes in an electrode-integrated microfluidic device2009

    • Author(s)
      Hashimoto M, Kaji H, Nishizawa M
    • Journal Title

      Biosens. bioelectron

      Volume: 24 Pages: 2892-2897

    • Peer Reviewed
  • [Journal Article] Controlled cocultures of HeLa cells and human umbilical vein endothelial cells on detachable substrates2009

    • Author(s)
      Kaji H
    • Journal Title

      Lab Chip

      Volume: 9 Pages: 427-432

    • Peer Reviewed
  • [Journal Article] Localized electrical stimulation to C2C12 myotubes cultured on a porous membrane-based substrate2009

    • Author(s)
      Ishibashi T, Hoshino Y, Kaji H, Kanzaki M, Sato M, Nishizawa M
    • Journal Title

      Biomed. Microdevices

      Volume: 11 Pages: 413-419

    • Peer Reviewed
  • [Presentation] PASCALを用いた網膜光凝固後の重篤な將液性網膜剥離2012

    • Author(s)
      岡村知世子、國方彦志、阿部俊明、針谷威寛、中澤徹
    • Organizer
      第35回日本眼科手術学会
    • Place of Presentation
      名古屋
    • Year and Date
      20120127-29
  • [Presentation] 東北大学病院における突発性傍中心窩毛細血管拡張症の特徴2011

    • Author(s)
      岡村知世子、國方彦志、新田文彦、阿部俊明
    • Organizer
      第50回日本網膜硝子体学会
    • Place of Presentation
      東京
    • Year and Date
      20111202-04
  • [Presentation] 網膜保護用のマルチドラッグデリバリーシステム2011

    • Author(s)
      永井展裕、大浪英之、梶弘和、山田琢也、佐藤真智子、西澤松彦、阿部俊明
    • Organizer
      第33回日本バイオマテリアル学会
    • Place of Presentation
      京都
    • Year and Date
      20111122-22
  • [Presentation] 網膜光障害モデルに対する経強膜DDSの網膜保護効果2011

    • Author(s)
      永井展裕、大浪英之、梶弘和、山田琢也、佐藤真智子、西澤松彦、阿部俊明
    • Organizer
      第33回日本バイオマテリアル学会
    • Place of Presentation
      京都
    • Year and Date
      20111121-22
  • [Presentation] Transscleral sustained delivery by novel device2011

    • Author(s)
      Nobuhiro Nagai, Toshiaki Abe
    • Organizer
      SDDS2011
    • Place of Presentation
      Chenzhen, China
    • Year and Date
      20111103-05
  • [Presentation] 経強膜ドラッグデリバリーデバイスの開発2011

    • Author(s)
      阿部俊明、永井展裕、大浪英之、中澤徹、梶弘和、西澤松彦
    • Organizer
      第65回日本臨床眼科学会
    • Place of Presentation
      東京
    • Year and Date
      20111007-10
  • [Presentation] 経強膜ドラッグデリバリーシステムによる網膜神経保護の試み2011

    • Author(s)
      永井展裕、熊坂典浩、大浪英之、川島丈明、梶弘和、西澤松彦、阿部俊明
    • Organizer
      第27回日本DDS学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20110609-10
  • [Presentation] Evaluation of Ocular Tissue Distribution of Drugs Delivered Transsclerally From A Non-biodegradable Polymeric Capsule Device2011

    • Author(s)
      Nobuhiro Nagai, Takeaki Kawashima, Hirokazu Kaji, Hideyuki Onami, Norihiro Kumasaka, Matsuhiko Nishizawa, Toshiaki Abe
    • Organizer
      ARVO2011
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      20110429-0506
  • [Presentation] Suppression of choroidal neovascularization by intravitreal vasohibin-1 in monkey eyes2011

    • Author(s)
      oshiaki Abe, Hideyuki Onami, Nobuhiro Nagai, Shigeki Machida, Norihiro Kumasaka, Ryosuke Wakusawa, Yumi Ishikawa, Hikaru Sonoda, Yasufumi Sato
    • Organizer
      ARVO2011
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      20110429-0506
  • [Presentation] 網膜変性疾患治療を目指したコラーゲン微粒子/ポリエチレングリコール複合体からなる薬剤徐放カプセルの作製と評価2011

    • Author(s)
      永井展裕、川島丈明、梶弘和、熊坂典浩、西澤松彦、阿部俊明
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京
    • Year and Date
      20110301-02
  • [Presentation] A novel membrane-based drug delivery capsule for retinal neuroprotection2010

    • Author(s)
      Nobuhiro Nagai, Takeaki Kawashima, Norihiro Kumasaka, Hirokazu Kaji, Matsuhiko Nishizawa, Toshiaki Abe
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      20101215-20
  • [Presentation] 徐放制御性に優れたPEGカプセルの作成と網膜DDSへの応用2010

    • Author(s)
      熊坂典浩、永井展裕、川島丈明、梶弘和、大浪英之、西澤松彦、阿部俊明
    • Organizer
      第32回日本バイオマテリアル学会
    • Place of Presentation
      広島
    • Year and Date
      20101129-30
  • [Presentation] Vasohibin and retinal pigment epithelium2010

    • Author(s)
      Toshiaki Abe, Hideyuki Onami, Norihiro Kumasaka, Yumi Tokita-Ishikawa, Hikaru Sonoda, Tomoaki Takakura, Yasufumi Sato, Nobuhiro Nagai
    • Organizer
      RD2010
    • Place of Presentation
      Mont-Tremblant, canada
    • Year and Date
      20100713-17
  • [Presentation] 糖尿病網膜症における非侵襲的皮膚AGE測定の有用性

    • Author(s)
      安田正幸、金澤紘子、國方彦志、新田文彦、阿部俊明、宮田敏男、中澤徹
  • [Presentation] 突発性黄斑円孔に対する硝子体手術成績とトリアムシノロンアセトニドの影響

    • Author(s)
      金澤紘子、國方彦志、安田正幸、新田文彦、鬼怒川次郎、中澤徹、布施昇男、阿部俊明
  • [Presentation] コラーゲン微粒子/ポリエチレグリコール複合体を用いた薬剤徐放カプセルの作製と評価

    • Author(s)
      川島丈明、永井展裕、梶弘和、西澤松彦、阿部俊明
  • [Book] 生理活性物質と眼疾患の基本、各種眼疾患と生理活性物質のかかわり、Behcet病2011

    • Author(s)
      阿部俊明
    • Total Pages
      1018-1020
  • [Remarks]

    • URL

      http://www.dcct.med.tohoku.ac.jp/

  • [Patent(Industrial Property Rights)] 持続性ドラックデリバリーシステム2010

    • Inventor(s)
      阿部俊明、永井展裕、梶弘和、川島丈明、西澤松彦、西田幸二
    • Industrial Property Number
      PCT/JP2010、63793
    • Filing Date
      2010-08-10
    • Overseas
  • [Patent(Industrial Property Rights)] 持続性ドラックデリバーシステム2010

    • Inventor(s)
      阿部俊明、永井展裕、梶弘和、川島丈明、西澤松彦、西田幸二
    • Industrial Property Number
      PCT/JP2010、63793
    • Filing Date
      2010-08-10
    • Overseas

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Published: 2013-07-31  

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