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2011 Fiscal Year Final Research Report

Investigation of role of glial cells in glaucomatous optic neuropathy and searching glial cell-related treatment for glaucoma

Research Project

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Project/Area Number 21592220
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionUniversity of Yamanashi

Principal Investigator

KASHIWAGI Kenji  山梨大学, 大学院・医学工学総合研究部, 准教授 (30194723)

Co-Investigator(Kenkyū-buntansha) MABUCHI Fumihiko  山梨大学, 大学院・医学工学総合研究部, 助教 (20322125)
CHIBA Tatsuya  山梨大学, 大学院・医学工学総合研究部, 助教 (50402061)
Project Period (FY) 2009 – 2011
Keywords緑内障 / グルタミン酸 / グルタミン酸トランスポーター / 眼グリア細胞 / 網膜神経節細胞 / 遺伝子改変マウス
Research Abstract

I clarified the following points ; Different glutamate transporters(GLT) were differently involved in glial cell-related effect on RGC. Major GLT, GLAST exerted neuroprotective effect on RGC, while GLT-1 exerted effect on promoting neuritis. Muller cells, major retinal glial cells, showed a protective effect on retinal ganglion cells(RGCs), while astrocytes in optic nerve did promoting effect of neurites. Several mRNAs influenced to RGC survival or neurite elongation were identified as key mRNAs for GLT-involved RGC effects. EGFR, Gabbr2, Agtr1a showed protective effect, while Id3、Egr1, Gja1p, App, Nr2f2 mRNAs were involved in RGC death. I developed an animal model that enables to observe axonal flow of lived rat retina.

  • Research Products

    (29 results)

All 2012 2011 2010 2009 2008 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (7 results) Book (4 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Role ofretinal glial cell glutamate transporters in retinal ganglion cell survival following stimulation of NMDA receptor2012

    • Author(s)
      Furuya T, Pan Z, Kashiwagi K
    • Journal Title

      Curr Eye Res

      Volume: 37(3) Pages: 170-8

    • Peer Reviewed
  • [Journal Article] Efficacy and safety of switching to travoprost/timolol fixed-combination therapy from latanoprost monotherapy2012

    • Author(s)
      Kashiwagi K
    • Journal Title

      Jpn J Ophthalmol

    • Peer Reviewed
  • [Journal Article] Comparing approaches to screening for angle closure in older Chinese adults2012

    • Author(s)
      Andrews J, Chang DS, Jiang Y, He M, Foster PJ, Munoz B, Kashiwagi K, Friedman DS
    • Journal Title

      Eye(Lond)

      Volume: 26(1) Pages: 96-100

    • Peer Reviewed
  • [Journal Article] Association between genetic variants associated with vertical cup-to-disc ratio and phenotypic features of primary open-angle glaucoma2012

    • Author(s)
      Mabuchi F, Sakurada Y, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S
    • Journal Title

      Ophthalmology

      Volume: Vol.119(in press)

    • Peer Reviewed
  • [Journal Article] Longitudinal Changes in Anterior Chamber Configuration in Eyes With Open-Angle Glaucoma and Associated Factors2012

    • Author(s)
      Pan Z, Furuya T, Kashiwagi K
    • Journal Title

      J Glaucoma

      Volume: 21(5) Pages: 296-301

    • Peer Reviewed
  • [Journal Article] Association between SRBD1 and ELOVL5 gene polymorphisms and primary open-angle glaucoma2011

    • Author(s)
      Mabuchi F, Sakurada Y, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: Vol.52 Pages: 4626-4629

    • Peer Reviewed
  • [Journal Article] A remote operating slit lamp microscope system. Development and its utility in ophthalmologic examinations2011

    • Author(s)
      Tanabe N, Go K, Sakurada Y, Imasawa M, Mabuchi F, Chiba T, Abe K, Kashiwagi K
    • Journal Title

      Methods Inf Med

      Volume: 50(5) Pages: 427-34

    • Peer Reviewed
  • [Journal Article] Comparison of the anterior ocular segment measurements using swept-source optical coherent tomography and a scanning peripheral anterior chamber depth analyzer2011

    • Author(s)
      Furuya T, Mabuchi F, Chiba T, Kogure S, Tsukahara S, Kashiwagi K
    • Journal Title

      Jpn J Ophthalmol

      Volume: 55(5) Pages: 472-9

    • Peer Reviewed
  • [Journal Article] Single versus sequential testing with scanning peripheral anterior chamber depth analyser IOLMaster and anterior segment optical coherence tomography for the detection of narrow angles.2011

    • Author(s)
      He MG, Lavanya R, Kashiwagi K, Friedman DS
    • Journal Title

      Br J Ophthalmol

      Volume: 95(10) Pages: 1410-4

    • Peer Reviewed
  • [Journal Article] Lack of association of common variants on chromosome 2p with primary open-angle glaucoma in the Japanese population2010

    • Author(s)
      Mabuchi F, Sakurada Y, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: Vol.107 Pages: E90-91

    • Peer Reviewed
  • [Journal Article] Estrogen receptor beta gene polymorphism and intraocular pressure elevation in female patients with primary open-angle glaucoma2010

    • Author(s)
      Mabuchi F, Sakurada Y, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S
    • Journal Title

      Am J Ophthalmol

      Volume: Vol.149 Pages: 826-830, e1-2

    • Peer Reviewed
  • [Journal Article] Change in trend of newly prescribed anti-glaucoma medications in recent nine years in a Japanese local community2010

    • Author(s)
      Kashiwagi K
    • Journal Title

      Open Ophthalmol J

      Volume: 28(4) Pages: 7-11

    • Peer Reviewed
  • [Journal Article] Lack of association between p53 gene polymorphisms and primary open angle glaucoma in the Japanese population2009

    • Author(s)
      Mabuchi F, Sakurada Y, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S
    • Journal Title

      Mol Vis

      Volume: Vol.15 Pages: 1045-1049

    • Peer Reviewed
  • [Journal Article] Changes in anterior chamber depth due to contusion2009

    • Author(s)
      Kashiwagi K, Tateno Y, Kashiwagi F, Tsukahara S
    • Journal Title

      Ophthalmic Res

      Volume: 42(4) Pages: 193-8

    • Peer Reviewed
  • [Presentation]2012

    • Author(s)
      Kashiwagi K
    • Organizer
      Genetics of Normal-Tension Glaucoma APAO
    • Place of Presentation
      Busan
    • Year and Date
      2012-04-15
  • [Presentation] Estrogen receptor beta遺伝子多型と眼圧の関連について2012

    • Author(s)
      間渕文彦,櫻田庸一,柏木賢治,山縣然太朗,飯島裕幸,塚原重雄
    • Organizer
      日本眼科学会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-06
  • [Presentation] Gene polymorphisms associated with optic nerve vertical cup-to-disc ratio are risk factors for primary open angle glaucoma2011

    • Author(s)
      Mabuchi F, Sakurada Y, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S
    • Organizer
      Annual Meeting of American Society of Human Genetics
    • Place of Presentation
      Montreal
    • Year and Date
      2011-10-14
  • [Presentation] 垂直C/D比に関与する遺伝子多型と原発開放隅角緑内障との関連について2011

    • Author(s)
      間渕文彦,櫻田庸一,柏木賢治,山縣然太朗,飯島裕幸,塚原重雄
    • Organizer
      日本緑内障学会
    • Place of Presentation
      秋田
    • Year and Date
      2011-09-24
  • [Presentation] How to detect and confirm progression and use it to manageglaucoma Stereoscopic optic disc viewing2011

    • Author(s)
      Kashiwagi K
    • Organizer
      Top ten pitfalls in identifying glaucoma damage and progression
    • Place of Presentation
      Paris
    • Year and Date
      2011-06-12
  • [Presentation] SRBD1gene polymorphism is associated with normal tension and high tension glaucoma2010

    • Author(s)
      Mabuchi F, Sakurada Y, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S
    • Organizer
      Annual Meeting of AmericanSociety of Human Genetics
    • Place of Presentation
      Washington DC
    • Year and Date
      2010-11-05
  • [Presentation] Association of the LOXL1 gene polymorphism with exfoliation syndrome after intraocular surgery2009

    • Author(s)
      Mabuchi F, Sakurada Y, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S
    • Organizer
      World Glaucoma Congress
    • Place of Presentation
      Boston
    • Year and Date
      2009-07-09
  • [Book] 専門医のための眼科診療クオリファイ2012

    • Author(s)
      柏木賢治
    • Total Pages
      122-132
    • Publisher
      中山書店
  • [Book] 眼手術学、6緑内障、レーザー隅角形成術2012

    • Author(s)
      柏木賢治
    • Total Pages
      332-336
    • Publisher
      文光堂
  • [Book] 眼科,病態生理(4)緑内障手術に関する最近の病態理解2011

    • Author(s)
      柏木賢治
    • Total Pages
      1327-1333
    • Publisher
      金原出版
  • [Book] Frontiers in Glaucoma抗緑内障治療薬の新規処方の変遷2011

    • Author(s)
      柏木賢治
    • Total Pages
      52-56
    • Publisher
      メディカル葵
  • [Remarks]

    • URL

      http://erdb.yamanashi.ac.jp/rdb/A_DispInfo.Scholar?ID=11CB59E63296DFFE

  • [Remarks]

    • URL

      http://sangaku.yamanashi.ac.jp/SearchResearcher/contents/11CB59E63296DFFE.html

  • [Patent(Industrial Property Rights)] 眼科用検査装置2011

    • Inventor(s)
      柏木賢治、中山淳二
    • Industrial Property Rights Holder
      山梨大学、タカギセイコー
    • Industrial Property Number
      実用特許、4878604
    • Acquisition Date
      2011-12-09
  • [Patent(Industrial Property Rights)] 眼科遠隔診断システム2008

    • Inventor(s)
      柏木賢治、郷健太郎、伊藤祐貴
    • Industrial Property Rights Holder
      山梨大学
    • Industrial Property Number
      実用特許、2008-284273
    • Filing Date
      2008-05-21

URL: 

Published: 2013-07-31  

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