2011 Fiscal Year Final Research Report
Investigation of susceptibility genes for primary open-angle glaucoma-Analysis of ESR2 gene polymorphisms-
| Project/Area Number |
21592221
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
MABUCHI Fumihiko 山梨大学, 大学院・医学工学総合研究部, 助教 (20322125)
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| Co-Investigator(Kenkyū-buntansha) |
SAKURADA Yoichi 山梨大学, 医学部附属病院, 助教 (90456476)
KASHIWAGI Kenji 山梨大学, 大学院・医学工学総合研究部, 准教授 (30194723)
YAMAGATA Zentaro 山梨大学, 大学院・医学工学総合研究部, 教授 (10210337)
IIJIMA Hiroyuki 山梨大学, 大学院・医学工学総合研究部, 教授 (80114362)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 緑内障 / estrogen receptor beta / ESR2 / 遺伝学 / 眼圧 / 遺伝子多型 |
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| Research Abstract |
Single nucleotide polymorphisms(SNPs) covering the whole region of estrogen receptor beta(ESR2) gene were genotyped in female patients with primary open-angle glaucoma(POAG) and the control subjects without glaucoma, and novel SNPs associated with intraocular pressure(IOP) were identified. These results strongly suggest that the ESR2 gene polymorphisms are associated with IOP regulation in women and IOP elevation in female patients with POAG.
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