2011 Fiscal Year Final Research Report
The identification and prevention of the mechanism of photoreceptor cell death
| Project/Area Number |
21592229
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAO Takeshi 大阪大学, 医学部附属病院, 医員 (00611170)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ゼブラフィッシュ / 網膜色素変性 / フォトトランスダクション / 神経保護 / アデニルシ |
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| Research Abstract |
We revealed that zebrafish photoreceptor cell death model ovl shows photoreceptor cell death which relates phototransduction cascade. The cell death mechanism connects at transducine with phototransduction via adenylyl cyclase. Then we established RP zebrafish model which possesses human Q344X mutated rhodoposin. The mechanism of photoreceptor cell death was observed in this model and other mammalian RP model and will be a novel target of RP theraphy.
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[Journal Article] Sayanagi K, Ikuno Y, Soga K, Wakabayashi T, Tsujikawa M, Tano Y2009
Author(s)
Sayanagi K, Ikuno Y, Soga K, Wakabayashi T, Tsujikawa M, Tano Y
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Journal Title
Br J Ophthalmol
Volume: 93
Pages: 1687-90
Peer Reviewed
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