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2011 Fiscal Year Final Research Report

Vascular maturation and its association with hematopoietic stem dells in intraocular neovascularization

Research Project

  • PDF
Project/Area Number 21592230
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionOsaka University

Principal Investigator

OSHIMA Yusuke  大阪大学, 医学系・研究科, 講師 (20362717)

Co-Investigator(Kenkyū-buntansha) GOMI Fumi  大阪大学, 医学系・研究科, 講師 (80335364)
IKUNO Yasushi  大阪大学, 医学系・研究科, 講師 (50294096)
KAMEI Motohiro  大阪大学, 医学系・研究科, 准教授 (40281125)
Project Period (FY) 2009 – 2011
Keywords血管内皮増殖因子 / 造血系幹細胞 / テノモジュリン / 眼内血管新生 / 増殖糖尿病網膜症 / 血管新生緑内障 / 未熟児網膜症
Research Abstract

In addition to the previously reported vascular endothelial growth factor, Stromal cell-derived factor 1α(SDF-1α) and its inducing endothelial progenitor cells can play important roles in neovascularization and vascular maturation in a variety of intraocular neovascular diseases such as proliferative diabetic retinopathy and neovascular glaucoma. The tendon-derived anti-angiogenic factor, tenomodulin, can suppress the intraocular neovascular activities via the interaction with these factors.

  • Research Products

    (8 results)

All 2012 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results) Book (1 results)

  • [Journal Article] Clinical outcomes and changes in aqueous vascular endothelial growth factor levels after intravitreal bevacizumab for iris neovascularization and neovascular glaucoma : a retrospective two-dose comparative study2012

    • Author(s)
      Sasamoto Y, Oshima Y, Miki A, Wakabayashi T, Song D, Matsushita K, Hamasaki T, Nishida K
    • Journal Title

      J Ocul Pharmacol Ther

      Volume: 28(1) Pages: 41-8

    • Peer Reviewed
  • [Journal Article] Microincision vitrectomy surgery and intravitreal bevacizumab as a surgical adjunct to treat diabetic traction retinal detachment2009

    • Author(s)
      Oshima Y, Shima C, Wakabayashi T, Kusaka S, Shiraga F, Ohji M, Tano Y
    • Journal Title

      Ophthalmology

      Volume: 116(5) Pages: 927-38

    • Peer Reviewed
  • [Presentation] Vitreoretinal surgery and pharmacotherapy for diabetic retinopathy and macular edema2010

    • Author(s)
      Oshima Y
    • Organizer
      The 25^<th> Congress of Asia-Pacific Academy of Ophthalmology, AOI-Symposium
    • Place of Presentation
      Beijing, China
    • Year and Date
      20100917-20
  • [Presentation] Aqueous humor levels of vascular endothelial growth factor before and after intravitreal bevacizumab in eyes with neovascular glaucoma2010

    • Author(s)
      Sasamoto Y, Oshima Y
    • Organizer
      World Ophthalmology Congress 2010
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      20100604-09
  • [Presentation] 重症増殖糖尿病網膜症の治療戦略: bevacizumabの功罪2010

    • Author(s)
      大島佑介
    • Organizer
      東京医科歯科大学眼科フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2010-01-31
  • [Presentation] Vitreoretinal surgery and pharmacotherapy for diabetic retinopathy and macular edema2009

    • Author(s)
      Oshima Y
    • Organizer
      Academia Ophthalmologica Internationalis Symposium, American Academy of Ophthalmology Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      20091024-27
  • [Presentation] 血管新生緑内障に対するbevacizumab硝子体内投与前後の前房内VEGF濃度変化2009

    • Author(s)
      佐々本弦、大島佑介
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-17
  • [Book] Principales and instrumentations. Vitreo-retinal Surgery Progress III. Series : Essentials in Ophthalmology2009

    • Author(s)
      Oshima Y, TanoY
    • Publisher
      Springer Inc

URL: 

Published: 2013-07-31  

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