2011 Fiscal Year Final Research Report
Pathogenesis of abnormal fundus autofluorescence and its relevance to age-related macular degeneration
Project/Area Number |
21592236
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | Nagoya City University |
Principal Investigator |
YASUKAWA Tsutomu 名古屋市立大学, 大学院・医学研究科, 准教授 (00324632)
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Co-Investigator(Kenkyū-buntansha) |
OGURA Yuichiro 名古屋市立大学, 大学院・医学研究科, 教授 (70191963)
NOZAKI Miho 名古屋市立大学, 大学院・医学研究科, 講師 (00295601)
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Project Period (FY) |
2009 – 2011
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Keywords | 眼細胞生物学 / 加齢黄斑変性 |
Research Abstract |
Age-related macular degeneration(AMD) is a major cause of legal blindness in the adult. Understanding of aging changes in eyes may be required to elucidate the pathogenesis of AMD and develop new prophylactic modalities. The first senescent change in the eye is the accumulation of lipofuscin, granules refractory to lysosomal degradation into retinal pigment epithelial cells. In this study, the rabbit AMD model was developed by injecting imitation lipofuscin into the subretinal space. This model revealed abnormal fundus autofluorescence similar to the findings observed in human aging eyes with or without AMD. This model mimicked the pathology of AMD and might be useful to elucidate the biogenesis of abnormal fundus autofluorescence and the pathogenesis of AMD.
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[Journal Article] Anti-angiogenic effects of the receptor tyrosine kinase inhibitor, pazopanib, on choroidal neovascularization in rats2011
Author(s)
Yafai Y, Yang XM, Niemeyer M, Nishiwaki A, Lange J, Wiedemann P, King AG, Yasukawa T, Eichler W
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Journal Title
Eur J Pharmacol
Volume: 666
Pages: 12-18
Peer Reviewed
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