2011 Fiscal Year Final Research Report
Functional analysis of mu-crystallin in intra ocular inflammation
| Project/Area Number |
21592250
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
OTA Koichi 松本歯科大学, 歯学部, 教授 (70262730)
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| Co-Investigator(Kenkyū-buntansha) |
KIKUCHI Takanobu 信州大学, ヒト環境科学研究支援センター, 教授 (50177797)
SUZUKI Satoru 信州大学, 医学(系)・研究科(研究院), 准教授 (30222061)
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| Co-Investigator(Renkei-kenkyūsha) |
IMAI Hiroki 信州大学, 医学部, 助教 (50568409)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 眼細胞生物学 |
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| Research Abstract |
Three types of murin intraocular inflammation model ; endotoxin-induced uveitis, experimental autoimmune uveoretinitis, and laser-induced choroidal neovascularization was established. The inflammation was mildly reduced in CRYM knock-out mice in all models. The CRYM may be associated with macrophages at second peak rather than neutrophils at first peak in anterior chamber of the eyes with EIU.
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