2011 Fiscal Year Final Research Report
Modulation of host environment in retinal cell transplantation using retinal degeneration models.
| Project/Area Number |
21592270
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MANDAI Michiko 独立行政法人理化学研究所, 網膜再生医療研究チーム, 研究員 (80263086)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Masayo 独立行政法人理化学研究所, 網膜再生医療研究チーム, チームリーダー (80252443)
HOMMA Kohei 独立行政法人理化学研究所, 網膜再生医療研究チーム, 研究員 (80462729)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 眼科学 / 再生医学 / 網膜変性 / 網膜移植 / 視細胞移植 |
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| Research Abstract |
Retinal degeneration models as were studied as a host for the acceptability of transplanted cells. Graft cells survived best when transplanted within a period of after the massive cell death and before the host gliosis progresses. In this time window, anti-inflammatory reagent and a synaptogenic factor enhanced graft cell(neonatal retinal cells) survival, and anti-gliotic reagent enhanced graft cell survival in later transplantation. We also prepared ES/iPS derived retinal cells for future practical transplantation experiments.
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