2011 Fiscal Year Final Research Report
Integrated study on the pathophysiology and treatment of pancreaticobiliary maljunction
| Project/Area Number |
21592275
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
KANEKO Kenitiro 名古屋大学, 大学院・医学系研究科, 准教授 (90335042)
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| Co-Investigator(Kenkyū-buntansha) |
ONO Yasuyuki 名古屋大学, 医学部附属病院, 講師 (10378193)
TAINAKA Takahisa 愛知医科大学, 特任准教授 (30378195)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 先天性消化器疾患学 / 先天性胆道拡張症 / 膵・胆管合流異常 / 蛋白栓 |
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| Research Abstract |
Based on the protein plug theory, we have developed a new therapy of endoscopic biliary drainage(EBD) for patients with persistent or exacerbated symptoms of pancreaticobiliary maljunction. The mechanism of carcinogenesis of pancreaticobiliary maljunction remains unknown. Microarray analysis and Real-time PCR identified 5 upregulatedgenes and one downregulated gene, including UCA1, DUOX2, DUOXA2, ID1, BMF, and GP2. UCA1, a noncoding RNA, is an oncofetal gene, and its upregulation may be important for biliary carcinogenesis
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