2011 Fiscal Year Final Research Report
Molecular biological analysis by organ culture and application to fetal treatment using mice model with anorectal malformation
| Project/Area Number |
21592276
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 直腸肛門奇形 / 器官培養 / 胎仔治療 |
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| Research Abstract |
A single high dose of etretinate, a long-acting synthetic retinoid, induces ARMs in mice. Abnormal intrinsic innervation of mice embryos with anorectal malformations at later developmental stages was eliminated by molecular biological methods. Organ culture was quite difficult, but it will be possible to succeed it. It is necessary to continue to study it.
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