2011 Fiscal Year Final Research Report

Study of the prevention of denervation muscle atrophy by using in-flow type end-to-side neurrhaphy

Research Project

Project/Area Number	21592291
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Plastic surgery
Research Institution	Fukushima Medical University
Principal Investigator	UEDA Kazuki 福島県立医科大学, 医学部, 教授 (40160163)
Project Period (FY)	2009 – 2011
Keywords	神経科学 / 脱神経性萎縮 / 端側型神経縫合
Research Abstract	The purpose of this study is to clarify whether flow-in end-to-side nerve anastomosis can prevent denervation atrophy of the muscle. In rats, the zygomatic branch was anastomosed with the side of the buccal branch, which was cut and immediately sutured at one or two portions proximal to the anastomotic site. Then, after the some period, the zygomatic branch was cut(donor release). As a result, the number of the regenerated axons was less distally than proximally to the anastomotic site in the one-portion-cut group, while it was more distally than proximally in the two-portions-cut group. It is recommended that flow-in end-to-side nerve anastomosis accompanied by donor release is recommended only for the nerve with severe damage