2011 Fiscal Year Final Research Report
Anti-inflammatory effect of hyperthermia on endothelial cells-temperature dependency and systemic response
| Project/Area Number |
21592315
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKURAI Atsushi 日本大学, 医学部, 助教 (40339320)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 高温 / サイトカイン / ヒト臍帯静脈血管内皮細胞 / interleukin(IL)-8 / IL-6 / 炎症 |
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| Research Abstract |
Hyperthermia is considered an important condition that may contribute to multiple organ failure(MOF) associated with endothelial cell damage. We demonstrated that endothelial cells may exhibit a temperature-dependent mechanism of cytokine interleukin(IL)-8releases and the suppression of cytokine protein production after transient hyperthermia stimuli even though an increased level of IL-8mRNA was observed. As there is a long-term effect of IL-6or8modulation after transient hyperthermia with increasing in mRNA expression after incubating endothelial cells under high-temperature stimuli, then the process might subsequently lead to neutrophil infiltration into the injured tissue, which in turn could worsen the outcome by enhancing secondary injury processes.
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