2011 Fiscal Year Final Research Report
Association between biofilm formation and amiloyd-like fiber in Aggregatibacter actinomycetecomitans
| Project/Area Number |
21592343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIHARA Kazuyuki (00212910)
KATO Tetsuo (00159253)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 口腔細菌学 / 付着 / バイオフィルム / 線毛 / アミロイド / 歯周病 / 歯周病原性菌 / Aggregatibacter actinomycetemcomitans |
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| Research Abstract |
Aggregatibacter actinomycetemocimitans is a pathogen of aggressive periodontitis. This microorganism has strong adherence activity and the ability plays an important role in its virulence. In this project, we intended to identify adherence factor including amyloid-like fiber other than fimbriae.
Amyloid-like fiber was detected by the thioflavin T floorescence assay. The amyloide-like fiber was fractionated with ion-exchange chromatography and gel chromatography. The fiber was stable after heat treatment and solubilization with the acidic buffer. The profile is resembled with the amyloid fiber of Escherichia coli.
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[Journal Article] Antimicrobial activity of super-oxidised water against oral microorganisms2010
Author(s)
Yamada, K., Yama, M., Takaku, Y., Kakizawa, T., Kimizuka, R., Okuda, K., Kato, T.
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Journal Title
Arch Oral Biol
Volume: 55
Pages: 397-400
DOI
Peer Reviewed
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[Journal Article] Congo red-binding protein in rough-phenotype aggregatibacter actinomycetemcomitans is amyloid-like fiber2009
Author(s)
Kimizuka, R., Kato, T., Hashimoto, S., Yamanaka-Okada, A., Okuda, K., Ishihara, K.
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Journal Title
Bull Tokyo Dent Coll
Volume: 50
Pages: 23-29
URL
Peer Reviewed
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