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2011 Fiscal Year Final Research Report

Reguraltory mechanisms of neuronal activity in the superior salivatory nucleus by feeding-related peptides.

Research Project

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Project/Area Number 21592361
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionOkayama University

Principal Investigator

MITOH Yoshihiro  岡山大学, 大学院・医歯薬学総合研究科, 助教 (20240872)

Co-Investigator(Kenkyū-buntansha) MATSUO Ryuji  岡山大学, 大学院・医歯薬学総合研究科, 教授 (30157268)
KOBASHI Motoi  岡山大学, 大学院・医歯薬学総合研究科, 准教授 (80161967)
FUJITA Masako  岡山大学, 大学院・医歯薬学総合研究科, 助手 (40156881)
ICHIKAWA Hiroyuki  東北大学, 大学院・歯学研究科, 教授 (20193435)
Project Period (FY) 2009 – 2011
Keywords口腔生理学 / 上唾液核ニューロン / 摂食関連ペプチド / ホールセルパッチクランプ法 / 免疫組織化学 / 視床下部 / 脳幹
Research Abstract

The superior salivatory nucleus(SSN) neurons which is the primary parasympathetic center of the submandibular and sublingual salivary glands in rats were excited by orexins, one of feeding-related peptides, from lateral hypothalamic neurons(feeding center). The excitation in SSN neurons was completely inhibited by antagonists for OX1R and OX2R, orexins receptors subtypes. Additionally, SSN neurons showed immunoreactivities for OX1R and OX2R, suggesting that the excitation is mediated by OX1R and OX2R. Orexin-induced excitation in SSN neurons may be involved in abundant salivation in feeding.

  • Research Products

    (25 results)

All 2012 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (19 results)

  • [Journal Article] Muscarinic receptor immunoreactivity in the superior salivatory nucleus neurons innervating the salivary glands of the rat.2011

    • Author(s)
      Ueda H, Mitoh Y, Fujita M, Kobashi M, Yamashiro T, Sugimoto T, Ichikawa H, Matsuo R.
    • Journal Title

      Neurosci Lett

      Volume: 499 Pages: 42-46

    • Peer Reviewed
  • [Journal Article] Central ghrelin inhibits reflex swallowing elicited by activation of the superior laryngeal nerve in the rat2010

    • Author(s)
      Kobashi M, Xuan SY, Fujita M, Mitoh Y, Matsuo R.
    • Journal Title

      Regul Pept

      Volume: 160(1-3) Pages: 19-25

    • Peer Reviewed
  • [Journal Article] Fourth ventricular administration of ghrelin induces relaxation of the proximal stomach in the rat2009

    • Author(s)
      Kobashi M, Yanagihara M, Fujita M, Mitoh Y, Matsuo R.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 296(2) Pages: R217-R223

    • Peer Reviewed
  • [Journal Article] Postnatal development of inhibitory synaptic transmission to superior salivatory neurons in rats.2009

    • Author(s)
      Mitoh Y, Funahashi M, Fujita M, Kobashi M, Matsuo R
    • Journal Title

      J Med Invest

      Volume: 56(Suppl) Pages: 270-272

  • [Journal Article] Cevimeline enhances the excitatory of rat superior salivatory neurons.2009

    • Author(s)
      Ueda H, Mitoh Y, Ichikawa H, Kobashi M, Yamashiro T, Matsuo R.
    • Journal Title

      J Med Invest

      Volume: 56(Suppl) Pages: 267-269

  • [Journal Article] Immunohistochemical study of the distribution and origin of GABAergic nerve terminals in the superior salivatory nucleus.2009

    • Author(s)
      Matsushima A, Ichikawa H, Fujita M, Mitoh Y, Kobashi M, Yamashiro T, Matsuo R.
    • Journal Title

      J Med Invest

      Volume: 56(Suppl) Pages: 264-266

  • [Presentation] 嚥下反射抑制におよほ & すオレキシンA作用部位の検討2012

    • Author(s)
      水谷諭史
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本
    • Year and Date
      2012-03-29
  • [Presentation] 精神ストレスと上唾液核への下降性ニューロンにおける神経調節機構2012

    • Author(s)
      松尾龍二
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-16
  • [Presentation] オレキシン中枢投与による反射性嚥下の抑制2011

    • Author(s)
      小橋基
    • Organizer
      第53回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-10-02
  • [Presentation] オレキシンはラット顎下腺・舌下腺を支配する上唾液核ニューロンの興奮性を促進する2011

    • Author(s)
      美藤純弘
    • Organizer
      第53回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-10-02
  • [Presentation] ラット大脳皮質咀嚼野の電気刺激が誘発するリズミカルな顎運動と唾液分泌の関連2011

    • Author(s)
      前田直人
    • Organizer
      第53回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-10-01
  • [Presentation] ラット中枢オレキシンによる反射性嚥下の抑制2011

    • Author(s)
      水谷諭史
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-28
  • [Presentation] ラット上唾液核へのGABA作動性抑制性入力に関する免疫組織化学的研究2010

    • Author(s)
      松島あゆみ
    • Organizer
      第52回歯科基礎医学会学術大会・総会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-21
  • [Presentation] 上喉頭神経刺激による背側迷走神経複合体でのc-fos発現ニューロン2010

    • Author(s)
      柳原衛
    • Organizer
      コ・メディカル形態機能学会第9回総会学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2010-09-11
  • [Presentation] ラット顎下腺・舌下腺支配の上唾液核ニューロンに対するセビメリンの作用機序2010

    • Author(s)
      美藤純弘
    • Organizer
      第19回神経行動薬理若手研究者の集い
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-15
  • [Presentation] Central ghrelin induces proximal stomach relaxation and inhibits refl ex swallowing in the anaesthetized rats2009

    • Author(s)
      Kobashi M
    • Organizer
      2009 International Symposium on Ghrelin
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-11-18
  • [Presentation] ラット上唾液核ニューロンに対するセビメリンの興奮性作用に関する電気生理学的および免疫組織化学的解析2009

    • Author(s)
      植田紘貴
    • Organizer
      第51回歯科基礎医学会学術大会・総会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-11
  • [Presentation] ラット上唾液核における抑制性受容体と抑制性ニューロンの中枢分布に関する免疫組織化学的研究2009

    • Author(s)
      松島あゆみ
    • Organizer
      第51回歯科基礎医学会学術大会・総会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-11
  • [Presentation] 摂食促進ペプチドによる食物受入と嚥下機能の調節作用、岡山大学大学院医歯薬学総合研究科2009

    • Author(s)
      小橋基
    • Organizer
      機能再生・再建科学専攻主催ミニシンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2009-08-11
  • [Presentation] GABAergic nerve terminals in the superior salivatory nucleus ; immunohistochemical and retrograde tracing study2009

    • Author(s)
      Mtsushima A
    • Organizer
      36th International congress of Physiological Sciences
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-31
  • [Presentation] Central ghrelin induces gastric relaxation of the proximal stomach via the caudal dorsal vagal complex in the rat2009

    • Author(s)
      Kobashi M
    • Organizer
      36th International congress of Physiological Sciences
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-30
  • [Presentation] Cevimeline enhances the excitability in the rat superior salivatory nucleus neurons2009

    • Author(s)
      Ueda H
    • Organizer
      36th International congress of Physiological Sciences
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-28
  • [Presentation] Postnatal development of inhibitory synaptic transmission to the superior salivatory neurons in rats2009

    • Author(s)
      Mitoh Y
    • Organizer
      The 11th International Symposium on Exocrine Secretion(ISES)
    • Place of Presentation
      Tokushima
    • Year and Date
      2009-07-24
  • [Presentation] Immunohistochemical study on the Distribution and origin of GABAergic nerve terminals in the superior salivatory nucleus2009

    • Author(s)
      Matsushima A
    • Organizer
      The 11th International Symposium on Exocrine Secretion(ISES)
    • Place of Presentation
      Tokushima
    • Year and Date
      2009-07-24
  • [Presentation] Cevimeline enhances the excitability in the rat superior salivatory nucleus2009

    • Author(s)
      Ueda H
    • Organizer
      The 11th International Symposium on Exocrine Secretion(ISES)
    • Place of Presentation
      Tokushima
    • Year and Date
      2009-07-24

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Published: 2013-07-31  

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