2011 Fiscal Year Final Research Report
The elucidation of the molecular mechanism in bone and cartilage destruction by IL-17supposing temporomandibular joint disorder
| Project/Area Number |
21592401
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nihon University |
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Principal Investigator |
MAENO Masao 日本大学, 歯学部, 教授 (60147618)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Naoto 日本大学, 歯学部, 教授 (10226532)
KAWATO Takayuki 日本大学, 歯学部, 講師 (50386075)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 顎関節症 / インターロイキン-17 / 骨芽細胞 / 破骨細胞前駆細胞 / 骨吸収 / 軟骨細胞 / 軟骨基質タンパク代謝 |
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| Research Abstract |
We examined the effects of IL-17on bone and cartilage destruction supposing temporomandibular joint disorder. The osteoclast differentiation and function of mature osteoclasts were suppressed in the direct stimulation by IL-17A to osteoclast precursors, whereas they were induced in the indirect stimulation via osteoblasts. IL-17A promoted the production of extracellular matrix proteins in osteoblasts. In addition, our results suggested that IL-17F suppresses the direction of synthesis in cartilage matrix protein metabolism, whereas it promotes the direction of destruction in the metabolism by chondrocytes.
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Research Products
(19 results)
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[Journal Article] Interleukin-17A induces cathepsin K and MMP-9expression in osteoclasts via celecoxib-blocked prostaglandin E2in osteoblasts2011
Author(s)
Zhang F, Tanaka H, Kawato T, Kitami S, Nakai K, Motohashi M, Suzuki N, Wang C, Ochiai K, Isokawa K, Maeno M
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Journal Title
Biochimie
Volume: 93(2)
Pages: 296-305
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