2011 Fiscal Year Final Research Report
Epithelotropism of effector cells in immune disorders of the oral mucosa
| Project/Area Number |
21592406
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
OHNO Jun 福岡歯科大学, 歯学部, 講師 (10152208)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 口腔粘膜疾患 / 免疫応答 / 上皮指向性 / エフェクター細胞 / satellitosis |
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| Research Abstract |
Epithelotropism of effector cells were studied in rat models of satellitosis-induced and lichenoid oral mucosal disorders. In the satellitosis-induced oral lesion, the induction of ICAM-1 expression on epithelial keratinocytes leads to the migration of CD8+cells into the epithelium. The lichenoid lesion is characterized by intense infiltration of class II+and ED1+cells around the epithelial basement membrane showing deposition of autoantibodies. These findings provided insights into the pathophysiological roles of effector cells in oral mucosal lesions.
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[Journal Article] A poly(gamma-glutamic acid)-amphiphile complex as a novel nanovehicle for drug delivery system2010
Author(s)
Akao T, Kimura T, Hirofuji YS, Matsunaga K, Imayoshi R, Nagao J, Cho T, Kaminishi H, Ohatono S, Ohno J, Taniguchi K
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Journal Title
J Drug Target
Volume: 18
Pages: 550-556
Peer Reviewed
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