2012 Fiscal Year Final Research Report

Mechanical strength improvement of carbonate apatite foam by regulatingorganic-inorganic interface

Research Project

Project/Area Number	21592498
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Dental engineering/Regenerative dentistry
Research Institution	Kyushu University
Principal Investigator	TSURU Kanji 九州大学, 歯学研究院, 准教授 (50314654)
Co-Investigator(Renkei-kenkyūsha)	ISHIKAWA Kunio 九州大学, 歯学研究院, 教授 (90202952)
Project Period (FY)	2009 – 2012
Keywords	インターフェイス / 有機-無機 / 炭酸アパタイト / 生体材料
Research Abstract	Carbonate apatite (CO_3Ap) foam which mimics the structure and inorganic composition of teeth and bone is expected for medical use as a bone substitute which can be replaced to new bone. However a mechanical strength improvement of CO3Ap is necessary. In this study, therefore, the mechanical strength improvement of CO_3 Ap was examined by regulating interface between organic and inorganic substances. Addition of 5wt% polyvinyl alcohol to precursor slurry enhanced interaction between precursor powders and polyurethane template and it affected to increase the compressive strength of obtained CO_3Ap foam. Besides, reinforcement of CO_3Ap foam was successfully achieved by coating with polylactic acid containing appropriate amount of CO3Ap granules without changing its morphology and composition.