2011 Fiscal Year Final Research Report
Properties of polysaccharide gel as a component of biofilms on the biomaterial surfaces related to the suppression of quorum sensing
| Project/Area Number |
21592499
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
NEZU Takashi 岩手医科大学, 歯学部, 講師 (40264056)
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| Co-Investigator(Renkei-kenkyūsha) |
ARAKI Yoshima 岩手医科大学, 歯学部, 教授 (20005036)
TAIRA Masayuki 岩手医科大学, 歯学部, 准教授 (60179398)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 生体材料 / バイオフィルム / 微生物 / 情報伝達 / 高分子構造・物性 |
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| Research Abstract |
The aim of this study was to investigate the properties of hyaluronic acid gel, which is an important component of biofilms, in order to find any physicochemical conditions leading to the suppression of the quorum sensing. An antimicrobial permeated more effectively through the hyaluronic acid gel when the gel viscosity was lowered. Addition of basic(cationic) antimicrobial surfactants was especially effective to lower the gel viscosity. Those findings would lead to the tactical inhibition of infection using a disturbance of the quorum sensing by interrupting the diffusion of autoinducers through the biofilm.
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