2011 Fiscal Year Final Research Report
Regenerative medicine for diabetic polyneuropathy using dental pulp stem cells
| Project/Area Number |
21592506
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
NARUSE Keiko 愛知学院大学, 歯学部, 准教授 (30387576)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUBARA Tatsuaki 愛知学院大学, 歯学部, 教授 (30209598)
TANAKA Yoshinobu 愛知学院大学, 歯学部, 教授 (60014271)
OZAWA Shogo 愛知学院大学, 歯学部, 准教授 (50323720)
NAKAMURA Jiro 愛知医科大学, 医学部, 教授 (40283444)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 歯髄幹細胞 / 糖尿病性神経障害 / 細胞治療 / 再生 |
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| Research Abstract |
In this study, we examined whether transplantation of rat or human DPSCs improve diabetic polyneuropathy. DPSCs were injected into unilateral hindlimb skeletal muscles of streprozotocin-induced diabetic animals. Transplantation of DPSCs ameliorated the decrease of sensation, sciatic nerve conduction velocity and sciatic nerve blood flow under the diabetic condition. Immunohistological study revealed that transplanted DPSCs existed in perimuscle bundle area without differentiation into osteoblasts or adipocytes. These results indicate that DPSCs are promising cell source for regenerative medicine and the transplantation of DPSCs may be a new therapy for diabetic polyneuropathy.
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