2011 Fiscal Year Final Research Report
New strategy for bisphosphonate-related osteonecrosis of the jaws assessed by FDG and FMISO PET imaging
| Project/Area Number |
21592510
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAGAWA Yoshimasa 北海道大学, 大学院・歯学研究科, 教授 (00224957)
HATA Hironobu 北海道大学, 大学院・歯学研究科, 助教 (70450830)
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| Project Period (FY) |
2009 – 2011
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| Keywords | FDG-PET / FMISO-PET / HBO / BRONJ |
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| Research Abstract |
Bisphosphonate-related osteonecrosis of the jaw(BRONJ) is known as a major side effect of bisphosphonates. The disease is serious, and treatment options are lacking. Hyperbaric oxygen(HBO) therapy for BRONJ is controversial. Moreover, in BRONJ, it is difficult to rule out the accurate extension of bone infection and necrosis using conventional radiographic methods. We evaluated the effectiveness of HBO therapy in patients with BRONJ using two types of PET. This study demonstrates FDG-PET may be a useful tool to monitor the effect of therapy in HBO and to predict prognosis in BRONJ, but FMISO-PET may not be applied for them.
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