2011 Fiscal Year Final Research Report
Bone tissue engineering using dental pulp cells cultured without osteogenic differentiation induction.
| Project/Area Number |
21592515
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YAMAGUCHI Satoshi 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (00280628)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 歯 / 歯髄 / 骨 / 再生医療 |
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| Research Abstract |
In a common strategy of bone tissue engineering, stem cells are differentiated into osteoblastic cells using differentiation-inducing agents. This study showed that human dental pulp cells cultured without osteogenic differentiation induction possessed the capacity to generate bone tissues in vivo. Furthermore, human dental pulp cells expanded in serum-free condition formed bone-like tissues in vivo. These results lead to set up a simple and safety strategy of bone tissue engineering like not previous.
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