2011 Fiscal Year Final Research Report
Neural plasticity of jaw movement system
| Project/Area Number |
21592522
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 神経可塑性 / 三叉神経 / 顎運動 / 脳幹 / パッチクランプ |
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| Research Abstract |
Applying brainstem transection techniques to the neonatal rat brainstem in vitro, we found that the activity of the motoneuron population recorded from the motor branch of the trigeminal nerve exhibited LTP-IE. We thus demonstrated the usefulness of this type of preparation for the study of rudimentary oral-motor activity and observed changes in TMN excitability. In addition, on testing with the whole-cell patch-clamp method, TMNs exhibited a significant increase in excitability with a leftward shift in F-I curves generated with depolarizing current injections. These findings indicate that TMNs exhibit LTP of intrinsic excitability. Blocking the calcium influx prevented LTP-IE. These results indicate that TMNs shows LTP-IE, and calcium influx is necessary for induction of LTP-IE.
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