2011 Fiscal Year Final Research Report
The evaluation of Bone Morphogenetic Protein-2(BMP-2) with autogenous bone marrow for the jaw defect.
| Project/Area Number |
21592524
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka Medical College (2011)
University of Fukui (2009-2010) |
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Principal Investigator |
UENO Takaaki 大阪医科大学, 医学部, 教授 (60252996)
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| Co-Investigator(Kenkyū-buntansha) |
YAMACHIKA Eiki 岡山大学, 大学病院, 講師 (10294422)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 骨再生 / 成長因子 / マイクロCT / 血管誘導 |
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| Research Abstract |
We investigated the osteogenic potential of a combination graft of autogenous bone marrow and bone morphogenetic protein(=BMP-2) in the rat calvarial defect. The newly formed bone was studied histologically and radiographically and compared with BMP-2 graft. Sixty days after grafting, the combination graft of autogenous bone marrow and BMP-2 showed new bone formation and no resorption of newly formed bone in the defect. The BMP-2 grafted in the defect showed bone formation and formed bone was resorbed at the edge of the defect. Total bone formation of the vombination of autogenous bone marrow and BMP-2 was obviously increased compared with BMP-2 graft. This result suggested that the newly formed vascularization was important event to increase and keep the volume of newly formed bone in the defect.
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[Journal Article] Effect of 2, 3, 7.8 tetrachlorodibenzo-p-dioxin suggests abnormal palate development after palatal fusion2010
Author(s)
Hideto Imura, Tomohiro Yamada, Katsuaki Mishima, Fujisawa H, Kawai H, Azumi Hirata, Noriyuki Sogawa, Takaaki Ueno, Toshio Sugahara
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Journal Title
Congeit Anom(Kyoto)
Volume: 50(2)
Pages: 277-284
Peer Reviewed
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