2011 Fiscal Year Final Research Report
Clarify the mechanism of reduction in the secretion of saliva on chronic sympathetic stimulation and these applications to human sensing
| Project/Area Number |
21592542
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kamakura Women's University |
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Principal Investigator |
YOSHINO Yoko 鎌倉女子大学, 家政学部, 講師 (70298248)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Yoichi 鶴見大学, 歯学部, 講師 (90148057)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ストレス / 唾液分泌 / カリクレイン / ERK1/2 / 細胞内Ca^<2+>濃度 |
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| Research Abstract |
We generated experimental system to clarify the mechanism of reduction in the secretion of saliva on chronic stress by administration of phenylephrine(α1 adrenergic receptor agonist) to mice. The salivary kallikrein activity in the PHE was significantly lower than that in the CTL. However analysis by proteomic suggested that amount of mk22 and Ren2 was decreased in the PHE, there was no significant difference in the expression of mRNA. On the other hand, the phosphorylation of ERK1/2 was increased in parotid gland, whereas it was decreased in submandibular gland. These results can be attributed to decrease of elevation of intracellular Ca^<2+>.
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Research Products
(14 results)
