2011 Fiscal Year Final Research Report
Studies on the regulation of differentiation of the pluripotent dental pulp stem cells by non-coding RNA
| Project/Area Number |
21592547
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 歯髄 / 幹細胞 / 多能性 / 分化転換 / 再生医学 |
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| Research Abstract |
To further evaluate the multipotency of dental pulp cells, and to investigate miRNA regulation of differentiation of these cells, we examined their in vitro differentiation into an endocrine cell lineage. After induction, insulin-producing cells were detected. Based on expression profiles by microRNA arrays, we identified targets, including molecules crucial for the differentiation into pancreatic beta cells. Thus, dental pulp cells have the potential to differentiate into an endocrine cell lineage by the regulation of miRNA following in vitro induction.
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