2011 Fiscal Year Final Research Report
An experimental study for development of real time diagnosis system for oral cancer treatment using nanobubbles and ultrasound
| Project/Area Number |
21592550
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MORI Shiro 東北大学, 病院, 講師 (80230069)
KODAMA Tetsuya 東北大学, 大学院・医工学研究科, 教授 (40271986)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 口腔癌 / ナノバブル / 超音波 / 術中迅速診断 / リアルタイム |
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| Research Abstract |
The aim of the present study is to develop a real time imaging diagnosis system for oral cancer using nanobubbles and high-frequency ultrasound. As a result, the following problems were revealed, halation caused by the ultrasound contrast agent, blurring of the image caused by arterial pulsation, and imaging of the immature angiogenesis of the tumor. On the other hand, the diagnostic accuracy could be improved by analyzing the four-dimentional dynamics of nanobubbles in the blood flow. In this stu dy, to solve the problems, hardware and software of the high frequency-ultrasound imaging system were improved
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Research Products
(15 results)
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[Journal Article] Evaluation of transfection efficiency in skeletal muscle using nano/microbubbles and ultrasound2010
Author(s)
Tetsuya Kodama, Atsuko Aoi, Yukiko Watabnabe, Sachiko Horie, Mizuho Kodama, Li Li, Rui Chen, Noriyoshi Teramoto, Hidehiro Morikawa, Shiro Mori, Manabu Fukumoto
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Journal Title
Ultrasound Med Biol
Pages: 1196
Peer Reviewed
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[Presentation] 頭頸部癌所属リンパ節転移の診断・治療に向けたリンパ節腫大マウスを用いたリンパ節転移モデルの開発2011
Author(s)
李麗, 森士朗, 柳下陽子, サックスニコラ, 堀江佐知子, 渡邊夕紀子, 高地崇, 李深偉, 宮下仁, 森川秀広, 阪本真弥, 小玉哲也
Organizer
第35回日本頭頸部癌学会
Place of Presentation
名古屋
Year and Date
20110609-10
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[Presentation] 口腔癌早期診断のためのナノバブルと高周波超音波を用いた画像診断法に関する組織学的検討2010
Author(s)
柳下陽子, 森士朗, 李麗, 渡邊夕紀子, 堀江佐知子, 冨田典子, 陳鋭, 高田陽子, 大木宏介, 宮下仁, 小玉瑞穂, 川村仁, 森川秀広, 小玉哲也
Organizer
第34回日本頭頸部癌学会
Place of Presentation
東京
Year and Date
20100610-11
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[Presentation] Volumetric and angiogenetic imaging system by using nanobubbles and high-frequency ultrasound for evaluation of the antitumor effect by cisplatin2010
Author(s)
Yagishita Y, Takata Y, Ohki K, Miyashita H, Morikawa H, Sakamoto M, Mori S, Kawamura H , Kodama T
Organizer
The 5th International Symposium on Medical, Bio-and Nano-Electronics
Place of Presentation
Sendai, Japan
Year and Date
20100224-25
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[Presentation] Longitudinal three-dimentional noninvasive imaging analysis and quantification of ant-tumor effects of TNF-alpha gene for small tumor2010
Author(s)
Sachiko Horie, Yukiko Watanabe, Yoko Yagishita, Nicolas Sax, Rui Chen, Li Li, Takanori Kojima, Hidehiro Morikawa, Maya Sakamoto, Masao Ono, Shiro Mori, Tetsuya Kodama
Organizer
2010 World Molecular Imaging Congress.(Oral Presentation : 0717A)
Place of Presentation
Kyoto, Japan
Year and Date
2010-09-08
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