2011 Fiscal Year Final Research Report
Identification of new predictive factors for chemo-radiation against oral cancers and setting of individualized medicine based on their expressions
| Project/Area Number |
21592555
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Yamaguchi University |
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Principal Investigator |
HARADA Koji 山口大学, 大学院・医学系研究科, 助教 (60253217)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 口腔癌 / 化学放射線療法 / 効果予測 / 耐性株 |
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| Research Abstract |
We established anticancer drug-resistant or radiation-resistant oral cancer cell lines. The specific fluctuating genes between a 5-FU-resistant cell line and a non 5-FU-resistant cell line were identified through microarray analysis, and we identified candidate genes including GDF15. We found a trifluorothymidine by investigating the agent can suppress the candidate gene expression. These finding suggested that trifluorothymidine based chemotherapy may be one of options for recurrent cases after 5-FU based chemotherapy.
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