2011 Fiscal Year Final Research Report
Chemoprevention for oral cancer targeting at microRNA
| Project/Area Number |
21592561
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Nara Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KUNIYASU Hiroki 奈良県立医科大学, 医学部, 教授 (00253055)
KIRITA Tadaaki 奈良県立医科大学, 医学部, 教授 (70201465)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | マイクロRNA / 口腔癌 / 化学予防 |
|---|
| Research Abstract |
We investigated the expression of microRNA(miRNA) has-miR29b-1 which is located on chromosome 7q32 and is considered to be related to the invasion and metastasis of oral cancer and the expression of c-Met as the target gene downregulated by has-miR29b-1 which is located in chromosome 7q31, in oral squamous cell carcinoma(OSCC) surgical specimens and cell lines. Then, correlation of these with clinical markers and phenotype of epithelial-mesenchymal transition was investigated.
|
Research Products
(29 results)
