2011 Fiscal Year Final Research Report
Application of EPC for tissue regeneration
| Project/Area Number |
21592566
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
ONO Mitsunobu 北海道大学, 北海道大学病院, 講師 (50281829)
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| Co-Investigator(Kenkyū-buntansha) |
HIDA Kyoko 北海道大学, 大学院・歯学研究科, 特任准教授 (40399952)
HIDA Yasuhiro 北海道大学, 北海道大学病院, 講師 (30399919)
SHINDOH Masanobu 北海道大学, 大学院・歯学研究科, 教授 (20162802)
HIGASHINO Fumihiro 北海道大学, 大学院・歯学研究科, 准教授 (50301891)
TOTSUKA Yasunori 北海道大学, 大学院・歯学研究科, 教授 (00109456)
KITAMURA Tetsuya 北海道大学, 大学院・歯学研究科, 助教 (00451451)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 血管新生 / 血管内皮前駆細胞 / 組織再生 |
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| Research Abstract |
EPC was isolated from peripheral blood using VEGFR2 and CD133 and they were cultured. Their angiogenic property was compared to normal endothelial cells(NEC). EPC showed higher levels of mRNA of growth factors and demonstrated activated angiogenic potential, ex, tube formation and cell migration in vitro. It was suggested that EPC may be contributed to tissue regeneration via their high angiogenic property.
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