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2011 Fiscal Year Final Research Report

Application of EPC for tissue regeneration

Research Project

  • PDF
Project/Area Number 21592566
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionHokkaido University

Principal Investigator

ONO Mitsunobu  北海道大学, 北海道大学病院, 講師 (50281829)

Co-Investigator(Kenkyū-buntansha) HIDA Kyoko  北海道大学, 大学院・歯学研究科, 特任准教授 (40399952)
HIDA Yasuhiro  北海道大学, 北海道大学病院, 講師 (30399919)
SHINDOH Masanobu  北海道大学, 大学院・歯学研究科, 教授 (20162802)
HIGASHINO Fumihiro  北海道大学, 大学院・歯学研究科, 准教授 (50301891)
TOTSUKA Yasunori  北海道大学, 大学院・歯学研究科, 教授 (00109456)
KITAMURA Tetsuya  北海道大学, 大学院・歯学研究科, 助教 (00451451)
Project Period (FY) 2009 – 2011
Keywords血管新生 / 血管内皮前駆細胞 / 組織再生
Research Abstract

EPC was isolated from peripheral blood using VEGFR2 and CD133 and they were cultured. Their angiogenic property was compared to normal endothelial cells(NEC). EPC showed higher levels of mRNA of growth factors and demonstrated activated angiogenic potential, ex, tube formation and cell migration in vitro. It was suggested that EPC may be contributed to tissue regeneration via their high angiogenic property.

  • Research Products

    (11 results)

All 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (5 results) Book (1 results)

  • [Journal Article] Heterogeneity of Tumor Endothelial Cells : Comparison between Tumor Endothelial Cells Isolated from Highly Metastatic and Low Metastatic Tumors2012

    • Author(s)
      Ohga N., Hida Y., Shindoh M., Hida K.
    • Journal Title

      Am J Pathol

      Volume: 180(3) Pages: 1294-1307

    • Peer Reviewed
  • [Journal Article] Tumor endothelial cells acquire drug resistance by MDR1 upregulation via VEGF signaling in tumor microenvironment2012

    • Author(s)
      Akiyama K., Hida Y., Shindoh M., Hida K.
    • Journal Title

      Am J Pathol

      Volume: 180(3) Pages: 1283-1293

    • Peer Reviewed
  • [Journal Article] Cyclooxygenase-2 inhibition causes antiangiogenic effects on tumor endothelial and vascular progenitor cells2011

    • Author(s)
      Muraki C., Hida Y., Totsuka Y., Shindoh M., Hida K.
    • Journal Title

      Int J Cancer

      Volume: 130 Pages: 59-72

    • Peer Reviewed
  • [Journal Article] HuR keeps an angiogenic switch on by stabilizing mRNA of VEGF and COX-2 in tumor endothelium2011

    • Author(s)
      Kurosu T., Hida Y., Totsuka Y., Shindoh M., Higashino F., Hida K.
    • Journal Title

      Br J Cancer

      Volume: 104(5) Pages: 819-829

    • Peer Reviewed
  • [Journal Article] Isolated tumor endothelial cells maintain specific character during long-term culture2010

    • Author(s)
      Matsuda K., Hida Y., Totsuka Y., Shindoh M., Hida K.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 394 Pages: 947-954

    • Peer Reviewed
  • [Presentation] 「口腔癌の浸潤-マクロ・ミクロ・モレキュラー」、"がんの浸潤転移と血管新生"2012

    • Author(s)
      樋田京子
    • Organizer
      第30回日本口腔腫瘍学会学術大会シンポジウム
    • Place of Presentation
      大宮ソニックシティ(大宮)
    • Year and Date
      2012-01-26
  • [Presentation] 「血管の多様性~組織発生から疾患におけるダイナミクス」、"Heterogeneity of Tumor Endothelium and Drug Resistance"2011

    • Author(s)
      樋田京子
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2011-06-29
  • [Presentation] 腫瘍血管内皮細胞の多様な生物像2011

    • Author(s)
      樋田京子
    • Organizer
      第27回日本DDS学会学術集会
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2011-06-09
  • [Presentation] 腫瘍血管内皮細胞の異常と新たな治療法の開発2010

    • Author(s)
      樋田京子
    • Organizer
      第64回日本口腔科学会学術集会
    • Place of Presentation
      札幌プリンスホテル(札幌)
    • Year and Date
      20100624-25
  • [Presentation] Crosstalk between tumor endothelial cells and microenvironment2010

    • Author(s)
      樋田京子
    • Organizer
      第56回日本病理学会秋期特別総会
    • Place of Presentation
      西日本総合展示場(北九州)
    • Year and Date
      2010-11-26
  • [Book] 血管生物医学事典2011

    • Author(s)
      樋田京子
    • Total Pages
      206-209
    • Publisher
      朝倉書店

URL: 

Published: 2013-07-31  

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