2011 Fiscal Year Final Research Report
The analysis of epigenetic events in rat togue carcinogenesis induced by 4-NQO
| Project/Area Number |
21592570
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Gifu University |
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Principal Investigator |
MAKITA Hiroki 岐阜大学, 大学院・医学系研究科, 講師 (50345790)
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| Co-Investigator(Kenkyū-buntansha) |
YONEMOTO Kazuhiro 岐阜大学, 医学部附属病院, 助教 (80422731)
KATO Keizo 岐阜大学, 医学部附属病院, 講師 (40397336)
SHIBATA Toshiyuki 岐阜大学, 大学院・医学系研究科, 教授 (50226172)
YAMASHITA Tomomi 岐阜大学, 大学院・医学系研究科, 准教授 (80345793)
TOIDA Makoto 岐阜大学, 大学院・医学系研究科, 准教授 (90313890)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 病態検査学 |
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| Research Abstract |
A high frequency of hepermethylation of p16 promoter was detected in tongue wquamous cell carcinomas(SCC), pre-cancerous lesions and some normal epithelia at 32 weeks from start of 4-NQO exposure. In SCC with higher p16 methylation level, loss of the protein expression was detected. Our results suggest p16 promoter hypermethylation may play an important role in development of 4-NQO induced tongue cancer in rat. Therefore, to understand human oral carcinogenesis, 4-NQO induced oral carcinogenesis model may be the best avalable model for epigenetic alterations.
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